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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-024-4 | CAS number: 113-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- For studies in humans no OECD guideline exist.
The study is well documentated including experimental details. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Calcium pyruvate
- EC Number:
- 257-599-9
- EC Name:
- Calcium pyruvate
- Cas Number:
- 52009-14-0
- Molecular formula:
- C3H4O3.1/2Ca
- IUPAC Name:
- calcium bis(2-oxopropanoate)
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- other: human
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: capsule
- Details on route of administration:
- Nine recreationally active subjects (8 women, 1 man; 64.9 +- 3.1 kg) consumed 7, 15, and 25 g of pyruvate.
- Vehicle:
- water
- Details on analytical verification of doses or concentrations:
- After consumation of the pyruvate blood samples were collected every 30 minutes for a 4-h period. Urine was collected throughout the duration of the 4-h period for analysis of the pyruvate content.
- Duration of treatment / exposure:
- daily, 7 d
Doses / concentrationsopen allclose all
- Dose / conc.:
- 25 other: g calcium pyruvate
- Dose / conc.:
- 15 other: g calcium pyruvate
- Dose / conc.:
- 7 other: g calcium pyruvate
- No. of animals per sex per dose:
- 8 women, 1 man
Results and discussion
Results of examinations
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 367.4 mg/kg bw/day (actual dose received)
- Based on:
- test mat. (total fraction)
- Sex:
- male/female
- Basis for effect level:
- haematology
- urinalysis
- Remarks on result:
- other: calcium pyruvate
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 25 other: g calcium pyruvate
- Based on:
- test mat. (total fraction)
- Sex:
- male/female
- Basis for effect level:
- haematology
- urinalysis
Target system / organ toxicity
- Key result
- Critical effects observed:
- no
- Lowest effective dose / conc.:
- 25 other: g calcium pyruvate
- System:
- other: no effect was observed in any system
- Organ:
- other: no effect was observed in any organ
Applicant's summary and conclusion
- Conclusions:
- Up to an daily uptake of 25 g calcium pyruvate for 7 days no adverse effects were observed.
Based on a body weight of maximum 68 kg this corresponds to 367.4 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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