Registration Dossier
Registration Dossier
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EC number: 608-462-0 | CAS number: 303186-20-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Resorption
Because of the molecular structure, low molecular weight and octanol-water partition coefficient (>5.7), resorption of the test item via the gastrointestinal tract is considered to be likely. After single treatment of rats with the test item (a homologues substance) at a dose of 2000 mg/kg bw no signs of toxicity were observed (acute oral: key study).
In a GLP-compliant OECD guideline 422 study with rats treated by gavage, adverse test item-related effects were observed at the lowest dose level of 5 mg/kg bw/day. They were observed in reproductive organs, including testes, epididymides and uterus. Remaining findings considered related to the treatment with the test item were present in thymus, thyroid glands, spleen , male liver, and male adrenal gland ).
This clearly shows a relevant absorbtion via the gastrointestinal tract.
Distribution
Due to the low water solubility and the high octanol/water-coefficient, in combination with the low molecular weight, permeation of membranes is assumed to be possible. The toxicological effects found in the repeat dose toxicity study of the substance (OECD 422, key study) clearly show that this compound is distributed throughout the body after oral uptake and is thus systemically available.
Metabolism and Excretion
Specific information on the metabolism and excretion of the substance is not available. From the OECD 422 study it can be conclududed, that metabolism in the liver can be assumed as a an increase in the liver weights was found. Due to the molecular properties, excretion via the kidneys is considered to be the main route of elimination.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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