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Diss Factsheets
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EC number: 257-581-0 | CAS number: 51988-14-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates
Read across to the Benzoic acid: OECD 202, Daphnia magna, static, EC50(48h): 7.04 (6.25–7.85) mmol/L, i.e. 860 mg/L.
Read across to DMTD: OECD 202, GLP compliance, Daphnia magna, static, EC50(48h): 5.95 mg/L
Toxicity to aquatic algae and cyanobacteria
Read across to DMTD: OECD 201, GLP compliance, Desmodesmus subspicatus (previous name: Scenedesmus subspicatus), static, EC50 (72h, growth rate): > 160 mg/L, NOEC(72h) 20mg/L, EC10(72h, growth rate): 32.86 mg/L
Read across to Benzoic acid: OECD 201, cyanobacteria (blue-green algae) Anabaena inaequalis, A. cylindrica, and A. variabilis, green algae Chlorella pyrenoidosa and Scenedesmus quadricauda, static, EC50 (12-14d): > 10 mg/L
Read across to Benzoate: Scenedesmus quadricauda, LOEC (96h, growth rate): 1630 mg/L
Additional information
The substance 5-mercapto-1,3,4-thiadiazole-2-thiol-benzoate is known to hydrolyse in aqueous solutions.Thus, a hydrolysis test was performed and hydrolysis products were identified in an OECD 111 Guideline study. 1,3,4-Dimercapto-thiadiazol (DMTD, CAS 1072-71-5) and benzoic acid (CAS 65-85-0) were identified as degradation products, where the parent compound's half life was 1.19 h. Therefore data on aquatic toxicity of the hydrolysis products were used in a weight-of-evidence approach.
The acute toxicity values for DMTD in an OECD 202 study with Daphnia magna of EC50(48h) 5.95 mg/L and in an OECD 201 study with Desmodesmus subspicatus of ErC50(72h) > 160 mg/L were below the acute toxicity values in daphnia for benzoic acid of EC50(48h) 860 mg/L and in algae for benzoate of 1630 mg/L, respectively. The lower values of DMTD have been used for hazard evaluation leading to the conclusion "not classified for aquatic toxicity".
Conclusion
Based on the results of the hydrolysis products the registered substance does not need to be classified as toxic to aquatic environment, neither acute nor chronic, according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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