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Diss Factsheets
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EC number: 208-609-5 | CAS number: 535-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl 2-bromopropionate
- EC Number:
- 208-609-5
- EC Name:
- Ethyl 2-bromopropionate
- Cas Number:
- 535-11-5
- Molecular formula:
- C5H9BrO2
- IUPAC Name:
- ethyl 2-bromopropionate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals weigh 150-180 g and were fed and drunk ad libitum.
Animals were submitted to a water diet of 17-19 hours before receiving the treatment and feed/water.
Temperature of 22°C, hygrometry of 50% and ventilation of 8 air renewals/hour.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- Preliminary test: 100, 500, 1000, 2500, 5000 mg/kg
Definitive test: 400, 440, 480, 580, 700 mg/kg - No. of animals per sex per dose:
- Preliminary test: 2 rats/sex/dose
Definitive test: 5 rats/sex/dose - Control animals:
- yes
- Details on study design:
- 1 preliminary test and 1 definitive test
- Statistics:
- 3 methods:
- Probit
- Litchfield and Wilcoxon
- Arcsinus
Results and discussion
- Preliminary study:
- At dose of 100 mg/kg, 0% of cumulated mortality after 14 days of observation.
At dose of 500 mg/kg, 50% of cumulated mortality after 14 days of observation.
At doses of 1000, 2500 and 5000 mg/kg, 100% of cumulated mortality after 14 days of observation.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 439 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 416 - <= 462
- Remarks on result:
- other: according to Litchfield and Wilcoxon method
- Mortality:
- At dose of 400 mg/kg, 20% of cumulated mortality after 14 days of observation.
At dose of 440 mg/kg, 50% of cumulated mortality after 14 days of observation.
At dose of 480 mg/kg, 80% of cumulated mortality after 14 days of observation.
At doses of 580 and 700 mg/kg, 100% of cumulated mortality after 14 days of observation. - Clinical signs:
- other: At dose of 400 mg/kg: from 1h to 6h, reduced spontaneous activity, apathy, ptosis. At day 1, normal behavior. At doses of 440 and 480 mg/kg: from 1h to day 1, reduced/no spontaneous activity, apathy, ptosis. At day 2, persistence of apathy. At day 3, norm
- Gross pathology:
- Observations during autopsy of dead animals under test:
At dose of 400 mg/kg: hemorrhagic lungs and thymus
At doses of 440 and 480 mg/kg: irritated stomach, hemorrhagic lungs and thymus in most of the animals
At doses of 580 and 700 mg/kg: same kind of symptoms as above.
Observations during autopsy of surviving animals at the end of the test:
At dose of 480 mg/kg: pale kidneys. This anomaly was not observed at doses of 400 and 440 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under experimental conditions, the LD50 by oral route in rats of Ethyl-2-bromopropionate is 439 mg/kg (416-462) according to Litchfield and Wilcoxon method.
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