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EC number: 219-868-9 | CAS number: 2556-10-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- November 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The acute fish toxicity for Hyacinth body is predicted using ECOSAR Neutral organics. The full justification is presented in the accompanying file attached in the Endpoint summary. The executive summary of the QSAR information is included in the Endpoint summary.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance R.6: QSARs and grouping of chemicals. Version May 2008
- Version / remarks:
- In the QMR attached the model specifications are presented. In this QMR is referenced to the Methodology document for the ecological Structure-Activity Relationship model (ECOSAR) Class Programm MS Windows v1.1'. United States Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington DC (2011).
- GLP compliance:
- no
- Test organisms (species):
- other: fish
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.2 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ECOSAR class: Neutral organics
- Validity criteria fulfilled:
- yes
- Remarks:
- The substance is within the applicability domain of the model and reliable and adequate documentation is present.
- Conclusions:
- The 96-h LC50 for fish is 7.2 mg/L.
Reference
Description of key information
The LC50 fish is 7.2 mg/l using ECOSAR Neutral Organic prediction.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.2 mg/L
Additional information
The 96h acute fish LC50 for the neutral organic substance Hyacinth body is predicted to be 7.2 mg/l based on the ECOSAR SAR for neutral organics using a measured log Kow of 3.5, molecular weight of 194.28 g/mol and the equation: 96h LC50(mg/L) = MW x 10^ (-0.8981 Log Kow + 1.7108).
Hyacinth body is in the applicability domain of the ECOSAR prediction because: a) Hyacinth body is a neutral organic presenting the toxicity solely by its bioavailability (i.e. without fragments that activate this neutral organic); b) its measured log Kow is 3.5 (predicted Log Kow = 2.91); c) its MW is 194.28 (=< 1000); and; d) the toxicity predicted is below its predicted water solubility of 152.3 mg/l (measured = 453 mg/L).
The results present some uncertainty compared to the data in the training set, because the difference between the predicted and the measured values for log Kow for Hyacinth body is greater than 0.5, which is outside IFF's validity criteria. The measured log Kow results in a more conservative acute fish toxicity value and therefore the measured value is used.
The fit in the applicability domain and the availability of an analogue in the training set results in limited uncertainty of the Hyacinth body prediction. This shows that the prediction is reliable and a Klimisch 2 can be assigned. In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for acute Fish toxicity on neutral organics (see attached report). The adequate and reliable documentation presented, further supports this prediction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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