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Diss Factsheets
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EC number: 231-912-9 | CAS number: 7778-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Materials and methods are well-documented in the publication. The tests were performed in accordance with U.S. EPA procedures.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. EPA EPA 600-R- 99-064
- Version / remarks:
- U.S. Environmental Protection Agency, 2000
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ASTM E1706 (Test Method for Measuring the Toxicity of Sediment-Associated Contaminants with Freshwater Invertebrates)
- Version / remarks:
- American Society for Testing and Materials International. 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. EPA Method 314.0 for the determination of perchlorate concentrations
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- Sodium perchlorate monohydrate (CAS 7791-07-3) with a purity of greater than 99.9% was purchased from Aldrich Chemical (Milwaukee, WI, USA) and used as received.
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples (125 ml) for perchlorate determination were collected directly from the middle of test chambers using a glass beaker and refrigerated, then shipped on ice to APPL Laboratories (Fresno, CA, USA) for analysis.
- Vehicle:
- no
- Details on sediment and application:
- The artificial sediment consisted of 76% fine silica sand, 20% kaolinite clay, and 4% fine peat moss (passed through a 500-μm mesh sieve).
- Test organisms (species):
- Chironomus dilutus (previous name: Chironomus tentans)
- Details on test organisms:
- Midges of Chironomus dilutus were obtained from egg masses produced by adult midges in cultures al ABC Laboratories.
The test was inithiated with the addition of 12 midge larvae into 12 replicate test chambers, for a total of 144 midges per treatment. The test chambers were glass jars holding a solution volume of approximately 500 ml and approximately 100 g of hydrated artificial sediment.
Four additional replicate test charnbers were initiated with the addition of 12 midge larvae on day 10 to provide additional male midges during the reproduction evaluation portion of the study. - Study type:
- laboratory study
- Test type:
- flow-through
- Water media type:
- freshwater
- Type of sediment:
- artificial sediment
- Limit test:
- no
- Duration:
- 42 d
- Exposure phase:
- total exposure duration
- Hardness:
- 140 to 162 mg/L as CaCO3
- Test temperature:
- 21 - 25 °C
- pH:
- 6.5 - 7.0
- Conductivity:
- 303 to 333 μS/cm
- Nominal and measured concentrations:
- nominal concentrations: 0 (control), 62.5, 125, 250, 500, 100, 2000 mg/L based on the perchlorate ion
measured concentrations: 58.5 to 2080 mg/L based on the perchlorate ion (93 - 104% of the nominal concentrations) - Details on test conditions:
- All tests wen: performed at ABC Laboratories (Columbia, MO, USA) under flow-through test conditions witb a proportional diluter system continuously delivering the test solutions at a rate of at least two complete test-system volume replacements per day.
light:dark period 16:8 h
Termperature, dissolved oxygen concentration, and pH were measured in all replicate solutions at test initiation, then weekly and again at test termination. - Key result
- Duration:
- 42 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 58.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- based on perchlorate ion
- Basis for effect:
- emergence rate
- Key result
- Duration:
- 42 wk
- Dose descriptor:
- LOEC
- Effect conc.:
- 118 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- based on perchlorate ion
- Basis for effect:
- emergence rate
- Key result
- Duration:
- 42 wk
- Dose descriptor:
- EC50
- Effect conc.:
- 208 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- based on perchlorate ion
- Basis for effect:
- mortality
- Conclusions:
- The NOEC was stated to be 58.5 mg/L based on the results of the Chironomus tentans life-cycle chronic toxicity test.
The LOEC was stated to be 118 mg/L based on the results of the Chironomus tentans life-cycle chronic toxicity test.
The EC50 was stated to be 208 mg/L based on the results of the Chironomus tentans life-cycle chronic toxicity test.
Reference
Survival rates:
nominal concentrations of perchlorate (mg/L) | measured concentrations of perchlorate (mg/L) | survival rate (%) |
0 (control) | 0 | |
62.5 | 58.5 | |
125 | 118 | |
250 | 233 | |
500 | 489 | |
1000 | 1020 | |
2000 | 2080 | |
control with sodium chloride at the same sodium concentration as that in the one or two highest sodium perchlorate treatment concentrations |
|
|
Most of the surviving larvae from exposure concentrations greater than 233 mg/L were discolored. However, this sublethal effect was not considered in the calculation of the EC50.
Description of key information
The NOEC was stated to be 58.5 mg/L based on the results of the Chironomus dilutus life-cycle chronic toxicity test.
The LOEC was stated to be 118 mg/L based on the results of the Chironomus dilutus life-cycle chronic toxicity test.
The EC50 was stated to be 208 mg/L based on the results of the Chironomus dilutus life-cycle chronic toxicity test.
Key value for chemical safety assessment
- EC50 or LC50 for freshwater sediment:
- 208 mg/kg sediment dw
- EC10, LC10 or NOEC for freshwater sediment:
- 58.5 mg/kg sediment dw
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.