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EC number: 206-017-1 | CAS number: 288-13-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Pyrazole
- EC Number:
- 206-017-1
- EC Name:
- Pyrazole
- Cas Number:
- 288-13-1
- Molecular formula:
- C3H4N2
- IUPAC Name:
- 1H-pyrazole
- Details on test material:
- Name of test substance: Pyrazol
Batch No.: Pyrazol 27/90
Purity: 100%
Date of manufacture: April 20, 1989
Physical state/appearance: solid (melt)/white-colourless
Storage conditions: was stored at room temperature
Stability: Stability was ensured for at least the study period.
Homogeneity: was guaranteed by purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- strain: SPF Wistar/Chbb : THOM ; breeding facility: Dr. K . Thomae GmbH, D-7950 Biberach, FRG)
Mean body weight at the beginning of the study: male animals 285 ± 4.0 g, female animals 188 ± 2 .1 g.
Age at the beginning of the study: approx . 8- 9 weeks
The animals were identified by color marking on the tail.
The animals were offered KLIBA rat/mouse laboratory diet 24-343-4 10 mm pellets, Klingentalmuhle AG, CH-4303 Kaiseraugst, Switzerland, and drinking water ad libitum during the post-exposure observation period.
The animals were kept in fully air-conditioned rooms in which a temperature in the range 20-24°C and relative humidity in the range 30-70% were regulated by means of a central air-conditioning system.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0.37 mg/L
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.37 mg/L air
- Remarks on result:
- other: maximum concentration achievable
- Mortality:
- No mortality was observed during the study.
- Clinical signs:
- other: Clinical signs included wiping of snouts, restlessness, and attempts to escape. All animals were clear of findings by 2 hours after the beginning of exposure.
- Body weight:
- The body weight gain of male rats was not affected. The body weight gain of the female rats was retarded in the second week of the observation period.
- Gross pathology:
- No pathologic findings noted.
Any other information on results incl. tables
Cumulated lethality on day |
male |
female |
0 |
0/5 |
0/5 |
1 |
0/5 |
0/5 |
2 |
0/5 |
0/5 |
7 |
0/5 |
0/5 |
14 |
0/5 |
0/5 |
Total at end of the study |
0/5 |
0/5 |
Time after beginning of exposure |
< ¼ h |
¼ h |
½ h |
1 h |
2 h |
3 h |
4 h |
Animals without findings |
10 |
10 |
10 |
||||
Wiping of snouts |
10 |
||||||
Restlessness |
10 |
10 |
10 |
||||
Attempts to escape |
10 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Regarding the results of the study, the LC50 of the test substance exceeds the maximum concentration that could be technically achieved (0.37 mg/L air).
- Executive summary:
The acute inhalation toxicity potential of the test substance was studied in accordance with OECD Guideline 403. Five male and five female rats were exposed to the test substance for 4 hours at a concentration of 0.37 mg/L (maximum attainable concentration). No mortality or gross pathologic findings were noted was observed.
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