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EC number: 217-682-2 | CAS number: 1929-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
LC50 = 2.20 mg/L (Daphnia magna Straus), EPA OPP 72-2, Weinberg (1991)
LC50 = 5.78 mg/L (Daphnia magna Straus), EPA publication method, McCarty (1977)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.2 mg/L
Additional information
Two studies, reporting the acute toxicity of the substance to aquatic invertebrates are available.
The key study, reported by Weinberg (1991), was conducted under GLP conditions and in accordance with the standardised guideline EPA OPP 72-2. It was assigned a reliability score of 1 in line with the criteria of Klimisch et al. (1997).
During the study, groups of 30 Daphnia magna Straus were exposed to solutions containing mean measured concentrations of active ingredient at 0.95, 1.50, 2.57, 4.00, 7.57 or 9.64 mg/L, a DMF control, or a laboratory water control, under flow-through conditions. The test vessels were observed daily for mortality and sub-lethal effects. All of the daphnia exposed to ≥ 7.57 mg/L died during the exposure period.
Under the conditions of the study, the 48 hour LC50 was determined to be 2.20 mg/L with a 95% confidence interval of 1.86 - 2.57 mg/L. Due to mortality at the lowest test concentration, the 48-hour mortality threshold concentration was less than 0.95 mg/L. Based on statistical analysis of the concentration/response data, the no-observed-effect concentration (NOEC) was calculated to be 1.50 mg/L.
Supporting information is available in the form of an acute toxicity study, as reported by McCarty (1977), which followed test methods described in the EPA publication "Methods for Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians". Since the study was not conducted under GLP conditions, and since reference was not made to standardised guidelines, it was assigned a reliability score of 2 in line with the criteria of Klimisch et al. (1997).
During the study three replicate groups of 10 Daphnia magna Straus were exposed to test material concentrations of 3.70, 5.60, 7.50, 10.00 and 13.50 mg/L, a dilution water control, or a solvent (acetone) control. The daphnia were observed for mortality at 24 and 48 hours. The control daphnia exhibited 10% mortality during the test. All daphnia exposed to the two highest test material concentrations of 13.50 mg/L, or 18.00 mg/L, died. Under the conditions of the study the 48 hour LC50 was determined to be 5.78 (4.97 - 6.54) mg/L.
The findings from the two studies are in good agreement with each other, however; being the key study, the LC50 value of 2.20 mg/L is taken forward for risk assessment.
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