Reaction mass of nonyl methacrylate and decyl methacrylate and undecyl methacrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: OSHA toxicity screening test. Limited documentation of the study.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Guideline:

other: OSHA Toxicity Screening Test

GLP compliance:

no

Test type:

other: saturated atmosphere

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Isodecyl methacrylate

EC Number:

249-978-2

EC Name:

Isodecyl methacrylate

Cas Number:

29964-84-9

Molecular formula:

C14H26O2

IUPAC Name:

8-methylnonyl methacrylate

Test animals

Species:

rat

Strain:

other: Albino

Details on test animals or test system and environmental conditions:

Average body weight: 190 grams

Administration / exposure

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: inhalation chamber
- Exposure chamber volume: 325 liter
- Source and rate of air: Air flow- thru generator, 9.9 L/min at 29.92 mm Hg
- Temperature: 25 °C
Time allotted for equilibrium: 161 min

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

1 h

Concentrations:

Average nominal concentration = 0.9 mg/L air

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC0

Effect level:

> 0.9 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

1 h

Mortality:

No deaths.

Clinical signs:

other: No untoward behavioral reactions.

Body weight:

The average body weight gain was 52 grams.

Gross pathology:

Necropsy examinations revealed no gross pathologicc alterations.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In an acute inhalation toxicity study on Isodecyl methacrylate with Albino Rats, no signs of toxicity were observed within a 14 day observation period after one-hour exposure to a saturated atmosphere (0.9 mg/L) at 35 °C.

Executive summary:

In an OSHA toxicity screening test in Albino rats on acute inhalation toxicity with Isodecyl methacrylate, no mortalities, behavioral abnormalities or gross pathologic alterations were observed after one hour exposure within a 14 day observation period.

The determined LC0 was > 0.9 mg/L at 35 °C (saturated atmosphere).

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