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EC number: 207-012-7 | CAS number: 422-05-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12-26 September 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Reference
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12-26 September 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to guidelines/standards)
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Visual observation of the test item
- GLP compliance:
- no
- Physical state at 20°C and 1013 hPa:
- liquid
- Form:
- liquid
- Remarks:
- clear
- Colour:
- colourless
- Substance type:
- organic
Based on test material information, the substance is a colourless clear liquid.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Adopted 24 February 1987
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,3,3,3-pentafluoropropanol
- EC Number:
- 207-012-7
- EC Name:
- 2,2,3,3,3-pentafluoropropanol
- Cas Number:
- 422-05-9
- Molecular formula:
- C3H3F5O
- IUPAC Name:
- 2,2,3,3,3-Pentafluoropropan-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD (SD)
- Remarks:
- Specific Pathogen Free
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Japanese Charles River, Atsugi, Kanagawa Prefecture, Japan
- Age at study initiation: 6 weeks
- Weight at study initiation: 110 - 150 g (males) and 90 - 120 g (females)
- Fasting period before study: animals were fasted overnight prior to administration
- Housing: stainless steel cages with mesh flooring
- Diet: CRF-1 pelleted, not further specified, ad libitum
- Water: filtered, UV sterilzated municipal tap water, ad libitum
- Acclimation period: at least seven days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 2
- Humidity (%): 55 ± 10
- Air changes (per hr): 15 - 17
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 12 September 1989 To: 26 September 1989
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: not specified
- Amount of vehicle (if gavage): not specified
- Justification for choice of vehicle: due to the lack of water solubility, olive oil was selected as a vehicle.
MAXIMUM DOSE VOLUME APPLIED:
body weight/100 x 1
- Doses:
- 1444, 1704, 2011, 2373 and 2800 mg/kg bw (males)
1229, 1536, 1920, 2400 and 3000 mg/kg bw (females) - No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed from 0 - 1, until 3, and until 6 hours post-administration on Day 0, then daily for 14 days. Individual body weights were taken on Days 0 (pre-administration), 1, 4, 7, 10, and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: histopathology. - Statistics:
- Male and female LD50s were calculated based on the Bliss method.
Body weight changes in the Dosed Groups were calculated by t-test versus the Control Group body weights.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 948 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 1 801 - ca. 2 105
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 826 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 1 646 - ca. 2 019
- Mortality:
- Control (0 mg/kg bw): 0/10 males
1444 mg/kg bw: 0/10 males
1704 mg/kg bw: 2/10 males, by end of Day 1
2011 mg/kg bw: 6/10 males, by end of Day 1
2372 mg/kg bw: 9/10 males, by Day 3
2800 mg/kg bw: 10/10 males, by end of Day 1
Control (0 mg/kg bw): 0/10 females
1229 mg/kg bw: 0/10 females
1536 mg/kg bw: 3/10 females, by Day 3
1920 mg/kg bw: 4/10 females, by the end of Day 1
2400 mg/kg bw: 10/10 females, by the end of Day 1
3000 mg/kg bw: 10/10 females, by the end of Day 1 - Clinical signs:
- In the observation of general symptoms: decline in self-mobility, ataxic gait, loss of aural, tactile, and righting reflexes, abnormal breathing, and prone and recumbent postures were observed immediately after administration of doses in cases of mortality. In addition, some cases where death occurred showed lacrimation, overturning, contamination, epistaxis discharge, and decreased body temperature, followed by death. When animals were found dead, lacrimation and epistaxis discharge were noted in some cases.
In the cases of survival: decline in self-mobility, ataxic gait, abnormal breathing, and hunched position were observed after administration of doses. In some cases of survival, overturning and contamination were observed, but all cases were resolved by Day 2. - Body weight:
- males
1444 mg/kg bw: significantly decreased (t-test; p ≤ 0.01) compared to control group
1704 mg/kg bw: significantly decreased (t-test; p ≤ 0.05) compared to control group
2011 mg/kg bw: significantly decreased (t-test; p ≤ 0.01) compared to control group
2372 mg/kg bw: significantly decreased (t-test; p ≤ 0.01) compared to control group
females
1229 mg/kg bw: decreased compared to control group
1536 mg/kg bw: significantly decreased (t-test; p ≤ 0.05) compared to control group
1920 mg/kg bw: significantly decreased (t-test; p ≤ 0.05) compared to control group - Gross pathology:
- Red lungs or lungs with red spots/macules, and thymus glands with red spots/macules were found for the male and females, in many found dead rats. Red fluid accumulation in the nasal cavity, nose contamination, lung subinvolution, and brown urine accumulation in bladder were found in some of the found dead rats. Periodic dissection cases showed lungs with red spots/macules for the males in some cases, in the dosed or control groups. There were no significant corresponding changes in the females in the dosed or control groups.
Any other information on results incl. tables
Acute Oral Toxicity
Dose [mg/kg bw] |
Mortality |
Clinical Signs |
Na |
Na |
|
Males |
||
1444 |
0/10 |
4/10 |
1704 |
2/10 |
9/10 |
2011 |
6/10 |
10/10 |
2372 |
9/10 |
10/10 |
2800 |
10/10 |
10/10 |
Females |
||
1229 |
0/10 |
9/10 |
1536 |
3/10 |
10/10 |
1920 |
4/10 |
10/10 |
2400 |
10/10 |
10/10 |
3000 |
10/10 |
10/10 |
aNumber of animals dosed
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 4 based on CLP criteria (EU criteria according to Regulation (EC) No. 1272/2008)
- Conclusions:
- Based on a single oral dose of the test material and mortality for 14 days, the following LD50 values were calculated using the Bliss method.
Male: LD50 1948 mg/kg (95% confidence limit: 1801-2105 mg/kg)
Female: LD50 1826 mg/kg (95% confidence limit: 1646-2019 mg/kg)
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