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Diss Factsheets
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EC number: 216-509-8 | CAS number: 1604-34-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- HET-CAM-Test
- Short description of test conditions: treatment of eggs with undiluted test substance and test substance 10 % in olive oil
- Parameters analysed / observed: time until onset of haemorrhagia, lysis, coagulation - GLP compliance:
- no
Test material
- Reference substance name:
- 6,10-dimethylundecan-2-one
- EC Number:
- 216-509-8
- EC Name:
- 6,10-dimethylundecan-2-one
- Cas Number:
- 1604-34-8
- Molecular formula:
- C13H26O
- IUPAC Name:
- 6,10-dimethylundecan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Tetrahydrogeranylaceton
- Substance No.: 01/0275-1
- Batch-Nr.: B 633
- Purity: 97.5 area% (GC)
- Date of production: 17 Oct 2000
- Substance type: Liquid / colourless - clear
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: BASF, Batch No. B 633
Test animals / tissue source
- Species:
- other: chorioallantoic membrane of hen´s egg (HET-CAM) Test
Test system
- Vehicle:
- other: undiluted and 10 % in olive oil Ph.Eur./DAB
- Controls:
- yes, concurrent positive control
- Amount / concentration applied:
- TEST MATERIAL
- undiluted
- Concentration (if solution): 100%, 10% - Duration of treatment / exposure:
- 5 minutes
- Observation period (in vivo):
- not applicable
- Number of animals or in vitro replicates:
- 3 eggs per dose group
- Details on study design:
- - Doses of test chemical and control substances used:
- test chemical: undiluted test substance and test substance 10 % in olive oil
- positive control: 0,1 N NaOH and 1 % SDS
- Duration of exposure: 301 s (5 min)
- Number of tissue replicates used per test chemical and controls (positive control): 3 eggs
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- other: Time (s) until appearance of haemorrhagia
- Remarks:
- undiltuted substance
- Run / experiment:
- mean of three eggs
- Value:
- 301
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: evaluated as no serious damage to eyes
- Irritation parameter:
- other: Time (s) until appearance of lysis
- Remarks:
- undiluted substance
- Run / experiment:
- mean of three eggs
- Value:
- 301
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: evaluated as no serious damage to eyes
- Irritation parameter:
- other: Time (s) until appearance of coagulation
- Remarks:
- undiluted substance
- Run / experiment:
- mean of three eggs
- Value:
- 150.7
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: evaluated as no serious damage to eyes
- Irritation parameter:
- other: Time (s) until appearance of haemorrhagia
- Remarks:
- Dilution of 10% in olive oil
- Run / experiment:
- mean of three eggs
- Value:
- 301
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: evaluated as no serious damage to eyes
- Irritation parameter:
- other: Time (s) until appearance of lysis
- Remarks:
- Dilution of 10% in olive oil
- Run / experiment:
- mean of three eggs
- Value:
- 301
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: evaluated as no serious damage to eyes
- Irritation parameter:
- other: Time (s) until appearance of coagulation
- Remarks:
- Dilution of 10% in olive oil
- Run / experiment:
- mean of three eggs
- Value:
- 301
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: evaluated as no serious damage to eyes
- Other effects / acceptance of results:
- The summary report does not state critiera for acceptance or interpretation of results.
Any other information on results incl. tables
Mean time (sec) until appearance of | ||||
test substance | Haemorragia | Lysis | Coagulation | Index for irritation |
10% | 301 | 301 | 301 | 0 |
100% | 301 | 301 | 150.7 | 4.5 |
0.1 N NaOH | 23 | 301 | 45,5 | 12,3 |
1% SDS | 45,3 | 301 | 75,0 | 11,0 |
0.1 N NaOH: Intravascular coagulation
1% SDS: Extra and intravascular coagulation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Procedure only excludes potential for severe eye irritation
- Conclusions:
- Based on these results it was concluded that the test substance Tetrahydrogeranylaceton does not represent a risk of serious damage to the eyes.
- Executive summary:
Fertilized eggs were incubated for 9-10 days. Then the eggs were opened and the CAM exposed. The undiluted test substance and a 10 % dilution in olive oil Ph.Eur./DAB were tested in 3 replicates each. The time until effects were observed was measured. Recorded effects were haemorrhagia, lysis and coagulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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