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Diss Factsheets
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EC number: 208-736-6 | CAS number: 540-10-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- Limited documentation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted in 2015
- Deviations:
- yes
- Remarks:
- Limited information on test substance, methods, no reading at 48 hours
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexadecyl palmitate
- EC Number:
- 208-736-6
- EC Name:
- Hexadecyl palmitate
- Cas Number:
- 540-10-3
- Molecular formula:
- C32H64O2
- IUPAC Name:
- hexadecyl hexadecanoate
- Test material form:
- solid
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other:
- Remarks:
- intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 500 mg of the product
- Concentration: pur product - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
Reading time points: 24 and 72 h - Number of animals:
- 6 male animals
- Details on study design:
- OBSERVATION TIME POINTS: 24 h and 72 h
SCORING SYSTEM:
- Method according to OECD GL 404 (Draize scoring system)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact skin and abraded skin
- Basis:
- animal #1
- Time point:
- other: mean after 24/48/72 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other:
- Remarks:
- for calculating the mean score, the 48 h values were assumed to be the same as for 24 h
- Irritation parameter:
- erythema score
- Remarks:
- intact and abraded skin
- Basis:
- mean
- Remarks:
- of 5 animals
- Time point:
- other: mean after 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other:
- Remarks:
- not applicable
- Remarks on result:
- other:
- Remarks:
- for calculating the mean score, the 48 h values were assumed to be the same as for 24 h
- Irritation parameter:
- edema score
- Remarks:
- intact skin and abraded skin
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean after 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other:
- Remarks:
- not applicable
- Remarks on result:
- other:
- Remarks:
- for calculating the mean score, the 48 h values were assumed to be the same as for 24 h
Any other information on results incl. tables
|
24 hours |
|
|
|
72 hours |
|
|
|
|
Erythema |
|
Oedema |
|
Erythema |
|
Oedema |
|
Animal |
intact skin |
incised skin |
intact skin |
incised skin |
intact skin |
incised skin |
intact skin |
incised skin |
#1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
#2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
#3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
#4 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
#5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
#6 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Method similar to OECD 404
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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