Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-055-7 | CAS number: 628-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There is no study available elucidating the skin sensitisation potential of butyl ethyl ether (target substance). Therefore, a skin sensitisation study conducted with di-n-butyl ether was used in a read-across approach. It was shown in this study, which was conducted equivalent to OECD testing guideline 406, that the source substance is considered not sensitising to the skin.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The source compound di-n-butyl ether (EC 205-575-3, CAS 142-96-1) is considered a suitable read across partner for butyl ethyl ether (EC 211-055-7, CAS 628-81-9). Both structures are short chain, linear alkyl ethers. The only difference in the structure is a C1-shorter (asymmetric) side chain in the butyl ethyl ether (C3-O-C4) compared to dibutyl ether (C4-O-C4).
Both ethers have similar physico-chemical properties. Both are water soluble (300 mg/L vs 2.88 g/L). Di-n-butyl ether has a slightly higher log Kow (3.35 vs 2.03), similar boiling points (140 °C vs 92.3 °C), melting point (-95 °C vs 124 °C), and self-ignition temperature (194 °C vs 180 °C) compared to butyl ethyl ether.
Based on the comparable log Kow and sufficing water solubility, it can be concluded that both compounds penetrate the skin to a similar extend, which would be a pre-requisite to elicit an immune response in the skin. From the structural similarity, it can also be concluded that both compounds have a similar behaviour in binding to proteins in the skin Therefore, it was concluded that the negative results from a skin sensitisation study in di-n-butyl ether can be used to predict the negative outcome in a skin sensitisation study with butyl ethyl ether. This assumption is further supported by the negative results in the OECD QSAR toolbox profiler (version 4.2). The profiler for Protein binding by OASIS and OECD predict “no alert found”, the Protein binding potency profiler for Cys and Lys predict “DPRA less than 9%”, and the endpoint specific profiler “Protein binding alerts for skin sensitisation according to GHS” or “[..] by OASIS”, as well as the “Protein binding potency h-CLAT” did not identify any alerts. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 4
- Total no. in group:
- 5
- Clinical observations:
- Erythema
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- Edema
- Group:
- negative control
- Remarks on result:
- not measured/tested
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was tested negative for skin sensitisation.
- Executive summary:
The present study explored the quantitative dermal exposure requirements for dermal sensitization in the guinea pig in relation to the concentration required for dermal response at challenge.
In this dermal sensitisation study (equivalent to OECD 406) guinea-pigs of the Hartley strain were tested. Test animals were challenged 5 days after induction. n-Butyl ether was used as vehicle. To exclude any reactions induced by n-butyl ether, a vehicle control was included in the test design (0.0 % test substance). At the 24-h reading no dermal reactions were seen in the vehicle application. Based on the results, n-butyl ether is not a dermal sensitiser.
This information on n-butyl ether is used in a read-across approach in the assessment of the substance to be registered.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data is available for butyl ethyl ether (target substance). Thus, available data from the suitable read-across partner di-n-buthyl ether (source substance) was used to assess the sensitising potential of the target substance. Di-n-butyl ether was tested negative in a dermal sensitisation study conducted equivalent to OECD 406. Based on the results from the read-across partner, the target substance butyl ethyl ether can be considered as not sensitising to the skin.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In a dermal sensitisation study conducted equivalent to OECD 406 a suitable read-across partner was tested negative for skin sensitisation. Based on the results from the read-across partner, no classification of butyl ethyl ether is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.