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EC number: 249-616-3 | CAS number: 29420-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- EC Number:
- 249-616-3
- EC Name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- Cas Number:
- 29420-49-3
- Molecular formula:
- C4HF9O3S.K
- IUPAC Name:
- potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Lot Number 2
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature, protected from light
FORM AS APPLIED IN THE TEST (if different from that of starting material): The test material was dissolved in 1% carboxymethylcellulose (CMC) in deionized water.
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc.
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: Six to eight weeks
- Weight at study initiation: Males 271.6 +/- 8.7g, females 183.6 +/- 8.7g
- Fasting period before study: Feed held over night prior to dosing
- Housing: The animals will be individually housed in stainless steel cages. The cages conform to standards set forth in the Guide for the Care and Use of Laboratory Animals, National Academy Press, Washington, D.C., 1996.
- Diet (e.g. ad libitum): Tekiad Certified Rodent Diet #8728 will be provided ad libitum. This diet is routinely analyzed by the manufacturer for nutritional components and environmental contaminants. Results of the manufacturer's analyses are on file at Primedica Redfleid.
- Water (e.g. ad libitum): Filtered tap water will be provided ad libitum. Samples of the water are analyzed for total dissolved solids, hardness, specified microbiological
content, and for environmental contaminants. Results of these analyses are on file at Primedica Redfield.
- Acclimation period: Animals will be acclimated for a minimum of seven days prior to the study start.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-26C
- Humidity (%): 30-70%
- Air changes (per hr): 10 or greater per hour
- Photoperiod (hrs dark / hrs light): 12:12 hour light:dark cycle
IN-LIFE DATES: From: 25 May 2000 To: 8 June 2000
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg
- Lot/batch no. (if required): 69H0028
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg
- Lot/batch no. (if required): 69H008
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
DOSAGE PREPARATION (if unusual): The vehicle was prepared to a concentration of 1% by mixing 10 grams of powdered medium viscosity carboxymethylcellulose with deionized water using a Waring blender. Additional deionized water was added to yield 1000 mL of prepared vehicle. The vehicle was stored refrigerated when not in use. The test material was dissolved in the prepared vehicle to the appropriate concentration and stirred on a magnetic stir plate.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Pretest and on study days 1, 8, and 15
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Observations for mortality and moribundity were recorded twice daily (a.m. and p.m.) with no incidence of either occurring throughout the study.
- Clinical signs:
- other: Clinical observationswere recorded predose and approximately hourly for four hours postdose on the day of dosing then daily thereafter for at least 14 days. Clinical observations included male localized alopecia, urine-stained abdominal fur, and one femal
- Gross pathology:
- On Study Day 15, all animals (non-fasted) were humanely euthanized via carbon dioxide asphyxiation followed by exsanguination and submitted for a complete necropsy examination. Necropsy examination failed to reveal any adverse findings with the exception of a single male and a single female with dilatation of the right kidney. Dilatation of the kidney is usually induced by hydronephritis of the kidney and this condition is not uncommon in rats. Therefore, these findings are not considered related to the test material.
Any other information on results incl. tables
Based on the results of the study, the rat oral LD50 of T-7485 is >2000 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the study, the rat oral LD50 of T-7485 is >2000 mg/kg.
- Executive summary:
The acute oral lethality of T-7485 was determined in rats. Crl:CD®(SD) IGS BR stock albino rats (5/sex/dose) received 2000 mg/kg T-7485 dissolved in carboxymethylcellulose via oral gavage. Observations for mortality and morbundity (twice daily), body weights (pretest and day 1, 8, and 15), clinical signs (predose and approximately hourly for 4 hours postdose on day 1 and daily thereafter for at least 14 days), and macroscopic examination (at necropsy). At 2000 mg/kg all animals survived. Clinical observations included male localized alopecia, urine-stained abdominal fur, and one female had liquid feces at three and four hours post dose. These clinical observations did not appear to be related to the test material exposure. Mean body weights increased in males (114.1 g) and females (49.4 g) between study day 1 and day 15, however, no record of body weight loss occurred during the study in either sex suggesting no adverse effect of a single 2000 mg/kg T-7485 dose. On study day 15 all animals (non-fasted) were euthanized and necropsied. Necropsy failed to reveal any adverse findings with the exception of dilation of the right kidney in one male and one female, however, this effect is usually induced by hydronephritis of the kidney and is not uncommon in rats; these findings were not considered related to the test material. Based on the results of the study, the rat oral LD50 of T-7485 is >2000 mg/kg.
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