Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-224-1 | CAS number: 68953-70-8 The complex combination of alkanolamines from the distillation of reaction products of ammonia and oxirane. It consists predominantly of triethanolamine, diethanolamine and higher amines from the reaction of triethanolamine and oxirane.
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 930
- Report date:
- 1930
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Patch test
- GLP compliance:
- no
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- - Name of test material (as cited in study report): Triethanolamine
- no further details
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Details on exposure:
- A patch of about 2 cm² in size was soaked with the liquid test materail and was applied to the upper arm of 6 volunteers, fixed by an adhesive tape. The patch was removed 24 hours later and skin irritation was assessed immediately upon patch removal and 24 hours later.
Results and discussion
- Clinical signs:
- 1 one case slight biting upon patch application combined with slight reddening was reported by one volunteer. No further clinical signs reported.
- Results of examinations:
- Upon patch removal no signs of skin irritation were apparent throughout the 6 volunteers. No further data reported.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
