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EC number: 203-728-9 | CAS number: 110-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetrahydrothiophene
- EC Number:
- 203-728-9
- EC Name:
- Tetrahydrothiophene
- Cas Number:
- 110-01-0
- Molecular formula:
- C4H8S
- IUPAC Name:
- tetrahydrothiophene
- Details on test material:
- Source: Pennwalt Corporation
Batch: 113-539-84
Purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton-Dutchland, Inc.3 , Denver, PA
- Age at study initiation: young adults
- Weight at study initiation: no data
- Housing: individually
- Diet (e.g. ad libitum): Lab Rabbit Chow HF (Purina #5326)
- Water (e.g. ad libitum): tap water
- Acclimation period: 20 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 60-70
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- Following approximately 4 hours of exposure, the wrappings and gauze square were removed and the test site gently wiped free of excess test material with gauze and water.
- Observation period:
- Approximately 4.5 hours (30 minutes after removal of wrappings), 24, 48 and 72 hours (3 days after the initial administration) and 7, 10 and 14 days after treatment or until no signs of Irritation were present.
- Number of animals:
- 6
- Details on study design:
- At interval all sites were evaluated for erythema and edema or other evidence of derrnal irritation according to the Draize scoring system. Adjacent areas of untreated skin were used for comparison. Special notation was made of necrosis, eschar, or other evidence of irreversible alteration of tissue structure.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- other: Fully reversible within 14 days, excepted for 1 animals
- Remarks on result:
- other: Superficial necrosis and eschar formation in 4/6 rabbits
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 1.05
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritant / corrosive response data:
- Tetrahydrothiophene produced only very slight (barely perceptible) to slight (well-defined) erythema and edema at 4.5 hours, but in four of the six animals tissue destruction (necrosis and eschar formation) became evident subsequently (between 24 hours and 7 days). Two animals showed no tissue destruction and were free of significant irritation within 2 to 10 days after test material application. Of the four animals which developed necrosis and eschar formation, three exhibited exfoliation of the eschar tissue with no significant residual irritation by Day 10 or 14 and one continued to exhibit eschar tissue at study termination (Day 14).
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Conclusions:
- Tetrahydrothiophene should be considered as irritant for the skin.
- Executive summary:
In a study performed according to EPA guideline #OPP 81-5 and GLP, 0.5 ml of Tetrahydrothiophene was applied for 4 hours under an occlusive dressing to the skin of 6 rabbits. Skin reactions were evalutated 30 min, 24, 48, 72 hours and 7, 10 and 14 days after the initial administration.
Tetrahydrothiophene produced only very slight (barely perceptible) to slight (well-defined) erythema and edema at 4.5 hours, but in four of the six animals tissue destruction (necrosis and eschar formation) became evident subsequently (between 24 hours and 7 days). Two animals showed no tissue destruction and were free of significant irritation within 2 to 10 days after test material application. Of the four animals which developed necrosis and eschar formation, three exhibited exfoliation of the eschar tissue with no significant residual irritation by Day 10 or 14 and one continued to exhibit eschar tissue at study termination (Day 14).
According to these results, tetrahydrothiophene should be considered as irritant for the skin.
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