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Diss Factsheets
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EC number: 907-132-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Prior to or in 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to guideline and/or standard method but was non-GLP.
- Justification for type of information:
- Read across is based on the category approach. Please refer to attached category document.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Committee on Methods for Toxicity Tests with Aquatic Organisms
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetraethylene Glycol
- IUPAC Name:
- Tetraethylene Glycol
- Reference substance name:
- 3,6,9-trioxaundecane-1,11-diol
- EC Number:
- 203-989-9
- EC Name:
- 3,6,9-trioxaundecane-1,11-diol
- Cas Number:
- 112-60-7
- Molecular formula:
- C8H18O5
- IUPAC Name:
- 2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
- Test material form:
- not specified
- Details on test material:
- Tetraethylene glycol was used. No additional information available.
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- Not applicable
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Stock solutions preparation and stability: Dissolution in dilution water
Exposure vessel type: 250 ml beakers with 200 ml test solution
Dilution water source: Kanawha River water, Charleston, West Virginia
Dilution water chemistry: Hardness 40-60 mg/L as CaCO3. Alkalinity 25-38 mg/L as CaCO3. pH 7.0-7.2. Conductivity 250 umhos/cm
Water chemistry (DO, pH) in test in the control and at least one concentration where effects were observed. pH = 6.9 –7.2 throughout test. DO was greater than 8.0 throughout test
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Source: Culture maintained in the laboratory for several years, initially stocked from the EPA laboratory at Duluth, Minnesota
Age at study initiation: Neonates <24 hours old were used
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No additional information available.
Test conditions
- Hardness:
- Hardness 40-60 mg/L as CaCO3
- Test temperature:
- 20 ± 2C
- pH:
- 7.0-7.2
- Dissolved oxygen:
- DO was greater than 8.0 throughout test
- Salinity:
- No data
- Nominal and measured concentrations:
- 0 (control), 3600, 6000, and 10,000 mg tetraethylene glycol/L
- Details on test conditions:
- Test design: 4 replicates per control and treatment, 5 test organisms per replicate.
Method of calculating mean measured concentrations: Nominal concentrations were used.
Exposure period: 48 hours
Analytical monitoring: Nominal concentrations were used - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7 746 mg/L
- Details on results:
- Remarks: Biological results: After 24 hours, there was 0% immobilisation in the controls and in the 3600 and 6000 mg/L treatments, and 85% immobilisation in the 10,000 mg/L treatment. After 48 hours, there was 0% immobilisation in the controls and in the 3600 and 6000 mg/L treatments, and 100% immobilisation in the 10,000 mg/L treatment
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Statistical results: LC50 = 7746 mg/L
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Tetraethylene glycol is practically non-toxic to Daphnia magna. LC50 = 7746 mg/L
- Executive summary:
The acute toxicity of tetraethylene glycol was examined with daphnia. After 24 hours, there was 0% immobilisation in the controls and in the 3600 and 6000 mg/L treatments, and 85% immobilisation in the 10,000 mg/L treatment. After 48 hours, there was 0% immobilisation in the controls and in the 3600 and 6000 mg/L treatments, and 100% immobilisation in the 10,000 mg/L treatment. The acute LC50 in daphnia was 7746 mg/L in this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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