Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-293-9 | CAS number: 520-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Circa 1950
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Dehydroacetic acid (DHA). III. Estimation, absorption, and distribution
- Author:
- Woods LA, Shideman FE, Seevers MH, Weeks JR & Kruse WT
- Year:
- 1 950
- Bibliographic source:
- J. Pharmacol. Exp. Ther. 99, 84-97
- Reference Type:
- publication
- Title:
- Chapter: 4 Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acid.
- Author:
- Cosmetic Ingredient Review
- Year:
- 1 985
- Bibliographic source:
- Journal of the American College of Toxicology; 4, No. 3, pp. 123-159,
Materials and methods
- Objective of study:
- absorption
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- EC Number:
- 208-293-9
- EC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- Cas Number:
- 520-45-6
- Molecular formula:
- C8H8O4
- IUPAC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- monkey
- Strain:
- not specified
- Details on species / strain selection:
- Not specified.
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Duration and frequency of treatment / exposure:
- 5 days/week for 290-397 days
Doses / concentrationsopen allclose all
- Dose / conc.:
- 50 mg/kg bw/day (nominal)
- Dose / conc.:
- 100 mg/kg bw/day (nominal)
- Dose / conc.:
- 200 mg/kg bw/day (nominal)
- No. of animals per sex per dose / concentration:
- 1
- Control animals:
- not specified
- Positive control reference chemical:
- Not specified.
- Details on dosing and sampling:
- Not specified.
- Statistics:
- Not specified.
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- Peak concentration occurred at 4.5 and 7 days after dosing.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Peak concentration occurred at 4.5 and 7 days after dosing. Plasma levels were 15, 26 to 33, and 45 to 51 mg/100 ml from lowest to highest dosage and diminished rapidly and progressively from high- to low-dose groups.
- Details on distribution in tissues:
- Not specified.
- Details on excretion:
- Not specified precisely.
Metabolite characterisation studies
- Metabolites identified:
- not specified
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- Not specified.
Applicant's summary and conclusion
- Conclusions:
- Peak concentration occurred at 4.5 and 7 days after dosing. Plasma levels were 15, 26 to 33, and 45 to 51 mg/100 ml from lowest to highest dosage.
Olive oil had no apparent effect on absorption. - Executive summary:
Monkeys (2 per dose group) received oral doses of 50, 100, and 200 mglkg bw/day, 5 days per week, for 290 to 397 days. Dehydroacetic Acid was administered in olive oil to 1 monkey in each group. Plasma concentrations of Dehydroacetic Acid were determined at various intervals after dosing. The peak concentration occurred between 4.5 and 7 hours after dosing (plasma levels at 4 hours from low dose to high were 15, 26 to 33, and 45 to 51 mg/l00 ml, respectively), and diminished rapidly and progressively from high- to low-dose groups. Olive oil apparently had no influence on absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.