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EC number: 205-840-3 | CAS number: 155-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute dermal and oral toxicity of the test substance ZMBT is very low, indicated by LD50 values greater than 5000 mg/kg. The acute oral LD50 value in rats is 7500 mg/kg bw mg/kg (Monsanto Co. 1975) and the dermal LD50 value in rabbits is greater than 7940 mg/kg bw (Monsanto Co. 1975).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- Method: other acute oral toxicity study
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 5000, 6310, 7940, 10000 mg/kg
- No. of animals per sex per dose:
- 5 combined males and females
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 7 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 6 820 - 8 250
- Remarks on result:
- other: clinical signs and death
Reference
Mortality
5000 mg/kg: male (0/3), female (0/2), combinded (0/5)
6310 mg/kg: male (1/2), female (0/3), combinded (1/5)
7940 mg/kg: male (1/3), female (2/2), combinded (3/5)
10000 mg/kg: male (2/2), female (3/3), combinded (5/5)
Time of mortality: One to two days after test substance application
Clinical signs:
Reduced appetite and activity (one to three days in survivors), increasing weakness, collapse, and death
Gross autopsy
Decedents: hemorrhagic areas of the lungs, liver hyperemia, and gastrointestinal inflammation
Survivors (14 day): viscera appeared normal
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 7 500 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- Method: other acute dermal toxicity study
- GLP compliance:
- no
- Test type:
- other: acute dermal toxicity study
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Duration of exposure:
- 24 h
- Doses:
- 7940
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: clinical signs like reduced appetite and activity
Reference
Mortality: no death occured during the study (0/2)
Clinical signs observed: reduced appetite and activity (two to four days)
Gross autopsy (survivors): viscera appeared normal
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 7 940 mg/kg bw
Additional information
Acute toxicity: oral
The acute oral toxicity of ZMBT was evaluated in acute oral toxicity studies in rats. Although the study designs do not fully comply with current guidelines the results are reliable.
In an acceptable documented study with Sprague-Dawley Albino rats a 20% solution-suspension of the test substance in corn oil was administered by gavage to male and female rats at doses of 5000, 6310, 7940 and 10000 mg/kg bw. A 14-day observation period followed administration. The oral LD50 calculated was 7500 mg/kg bw. Mortality occurred (one to two days after application) in the mid and higher dose groups evaluated (0/5, 1/5, 3/5, 5/5 at 5000, 6310, 7940 10000 mg/kg bw, respectively). Clinical signs were observed and included reduced appetite and activity (one to three days in survivors), increasing weakness, collapse and death. Autopsy of decedent showed hemorrhagic areas of the lungs, liver hyperemia, and gastrointestinal inflammation; viscera of surviving animals appeared normal at sacrifice (Monsanto Co. 1975).
In a limited acute toxicity study with rats, a LD50 value greater 10000 mg/kg bw is suggested (TNO 1975). Male and female rats (10 per sex) were administered once by gavage with the test substance, which was suspended in propylene glycol (33 % w/v). After the treatment the rats were observed for signs of intoxication for 14 days. Autopsy was carried out at study termination. Two males and two females died 2 to 15 hours after treatment. Clinical signs occurred within a few minutes after treatment. All treated animals showed sluggishness followed by loss of consciousness (dosing volume 30ml/kg). After 24 hours the survivors recovered and looked quite healthy at study termination.
Acute toxicity: dermal
The acute dermal toxicity of ZMBT was evaluated in a limited but acceptable documented acute dermal toxicity study with New Zealand Albino rabbits (Monsanto Co. 1975). One male and one female rabbit were treated with 7940 mg/kg ZMBT (40% test substance solution-suspension in corn oil) for 24 hours. No mortality occurred during the study. Clinical signs observed included reduced appetite and activity (two to four days). Gross autopsy at study termination revealed no abnormalities in viscera in the treated animals. A dermal LD50 value greater than 7940 mg/kg bw is suggested.
Justification for classification or non-classification
No classification is required according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
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