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EC number: 605-263-0 | CAS number: 161611-74-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 22 December 2015 to 12 December 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The maximum deviation of the mean concentrations in the tests samples was >15%. Due to the high volatiliy of the test item and despite all the precautions taken, it was not possible to avoid evaporation of the test item and so reduce the maximum deviation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The maximum deviation of the mean concentrations in the tests samples was >15%. Due to the high volatiliy of the test item and despite all the precautions taken, it was not possible to avoid evaporation of the test item and so reduce the maximum deviation
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: slow stirring flask method
- Key result
- Water solubility:
- 0.214 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20.1 °C
- pH:
- 5.1
- Key result
- Water solubility:
- 0.068 g/L
- Incubation duration:
- 48 h
- Temp.:
- 20.1 °C
- pH:
- 6.4
- Key result
- Water solubility:
- 0.136 g/L
- Incubation duration:
- 72 h
- Temp.:
- 20.1 °C
- pH:
- 6.6
- Conclusions:
- The slow-stirring flash method was applied for the determination of the test item .
The water solubility at 20°C was estimated to be 0.139 g/L.
The pH of the aqueous samples was 5.1 to 6.6 - Executive summary:
The water solubility of the test item was determined with slow stirring flask method according to recognized guidelines (OECD Guideline 105,EU Method A.6 and EPA OPPTS 830.7840) and GLP.
A deviation from the guideline was observed during the study. The maximum deviation of the mean concentrations in the tests samples was >15%. Due to the high volatiliy of the test item and despite all the precautions taken, it was not possible to avoid evaporation of the test item and so reduce the maximum deviation
The water solubility at 20°C was estimated to be 0.139 g/L.
The pH of the aqueous samples was 5.1 to 6.6
Reference
Preliminary test:
The content of test item dissolved in the water sample was 0.0483 g/L. Based on this results and the high volatility of the test item, the slow stirring flask method have been used in the main test.
Main study:
The results for the sample taken after 24, 48 and 72 hours at 20.1 +/-0.3°C are given in the table below:
Stirring time | Replicate | Analysed concentration | Mean | Mean1 | MD2 | pH |
[g/L] | ||||||
[hours] | [g/L] | [g/L] | [%] | |||
24 | A | 0.303 | 0.214 | 0.139 | 103 | 5.1 |
B | 0.117 | |||||
C | 0.221 | |||||
48 | A | 0.148 | 0.0681 | 6.4 | ||
B | 0.0221 | |||||
C | 0.0344 | |||||
72 | A | 0.0913 | 0.136 | 6.6 | ||
B | 0.260 | |||||
C | 0.0563 |
The maximum difference (MD) of the mean concentrations determined in the tests samples was higher than 15%, regardless of the preparation of the samples with special precaution in order to avoid as much as possible the evaporation of the test item. However due to the high volatility, the water solubility of the test item is given as en estimated value based on the mean of all the concentration.
No test item was detected in the pretreated sample from the blank water mixture.
Description of key information
The water solubility of the test item was determined with slow stirring flask method according to recognized guidelines (OECD Guideline 105,EU Method A.6 and EPA OPPTS 830.7840) and GLP.
A deviation from the guideline was observed during the study. The maximum deviation of the mean concentrations in the tests samples was >15%. Due to the high volatiliy of the test item and despite all the precautions taken, it was not possible to avoid evaporation of the test item and so reduce the maximum deviation
Key value for chemical safety assessment
- Water solubility:
- 0.139 g/L
- at the temperature of:
- 20.1 °C
Additional information
The pH of the aqueous samples was 5.1 to 6.6
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