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EC number: 272-599-9 | CAS number: 68892-13-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 25-JAN-1995 (animal arrived) to 17-FEB-1995 (observation period completed)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-phenyldecane-1,3-dione
- EC Number:
- 272-599-9
- EC Name:
- 1-phenyldecane-1,3-dione
- Cas Number:
- 68892-13-7
- Molecular formula:
- C16H22O2
- IUPAC Name:
- 1-phenyldecane-1,3-dione
- Details on test material:
- - Name of test material (as cited in study report): RHODIASTAB X2
- Substance type: no data
- Physical state: opaque dark amber liquid and gold solid
- Analytical purity: the analytical purity was the responsability of the Sponsor
- Purity test date: the purity test date was the responsability of the Sponsor
- Lot/batch No.: 9330912
- Expiration date of the lot/batch: no data
- Stability under test conditions: the stability under the storage conditions below was the responsability of the Sponsor
- Storage condition of test material: the test substance was stored at ambient temperature in the Sponsor original container
- Other: the test substance was received on 30 December 1994.
Rhodiastab X2 is the previous name of the same test substance currently commercialised as Rhodiastab 92.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD strain (remote Sprague-Dawley origin)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Age at study initiation: approximately five weeks old
- Weight at study initiation: 122-146 g for males (body weight at the day prior to dosing) and 130-146 g for females (body weight at the day prior to dosing)
- Fasting period before study: yes
- Housing: five animals (same sex/cage) were housed in stainless grid cages (R.S. Biotech, England) where the grid floors ensured rapid removal of waste material to undertrays which were cleaned out as necessary. The cages were suspended in mobile stainless steel racks.
- Diet (e.g. ad libitum): complete pelleted rodent diet (RMI(E)SQC, Special Diets Services Limited, England), ad libitum. Batch analytical data were supplied by the manufacter.
- Water (e.g. ad libitum): tap water from the public supply (Department of the Environmental regulations, England). Analytical certificates were routinely received from the suplier (Suffolk Water Company).
- Acclimation period: at least five days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25°C
- Humidity (%): 40-70 %
- Air changes (per hr): at least 10 complete air changes/hour without re-circulation.
- Photoperiod (hrs dark / hrs light): 12 hours/day
IN-LIFE DATES: From: 3-FEB-1995 To: 17-FEB-1995
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: appropriate concentration to permit administration at a constant volume-dosage of 10 mL/ kg b.w. (no other details)
- Amount of vehicle (if gavage): no data
- Justification for choice of vehicle: no data
- Lot/batch no. (if required): no data
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg b.w.
DOSAGE PREPARATION (if unusual): / - Doses:
- 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5 rats/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (animal sacrifice on day 15)
- Frequency of observations and weighing: the day before dosing, day 1, 8 and 15
- Necropsy of survivors performed: yes (larger organs were sectioned and the gastro-intestinal tract was opened at intervals for examination of the mucosal surfaces. No tissues were retained in fixative.
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: three separate recordings of signs during the first hour after dosing and 2 further recordings during the remainder of day 1. From day 2 onwards, the animals were inspected twice daily and recordings were made once daily. - Statistics:
- No data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: No clinical signs were observed during the 14-day observation period.
- Gross pathology:
- Necropsy conduted on day 15 showed no significant abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 value of Rhodiastab X2 in SD rats was established to exceed 2000 mg/kg body weight.
Based on these results, 1-Phenyldecane-1,3-dione does not have to be classified and has no obligatory labelling requirement for acute oral toxicity according to the GHS and CLP regulations. - Executive summary:
Rhodiastab X2 (former commercial name of the registered substance) has been tested for acute oral toxicity in CD rats according to OECD guidelines 401 and Directive 92/69/EEC method B1, and in compliance with Good Laboratory Practices. The test substance was administered at a dosage of 2000 mg/kg b.w. to a group of 5 males and 5 females, at a constant volume of 10 mL/kg in maize oil. Examinations for mortality, body weight gain and abnormal clinical signs were performed during the 14-day study period.
No death and no clinical signs were observed during the study. The general behaviour and body weight gain were not affected by treatment. At necropsy, a macroscopic examination revealed no abnormality .
Under the conditions of the test, as the LD50 is higher than 2000 mg/kg b.w., Rhodiastab X2 is not classified according to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) and Regulation (EC) No 1272/2008 (CLP).
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