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EC number: 226-942-4 | CAS number: 5570-77-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1962, 23:2, 95-107
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The skin irritation test was conducted on five rabbits’ belly to assess the degree of skin irritation of test chemical 1-methylpiperazine (CAS No: 109-01-3).
Test material
- Reference substance name:
- 1-Methylpiperazine
- Cas Number:
- 109-01-3
- Molecular formula:
- C5H12N2
- IUPAC Name:
- 1-Methylpiperazine
- Test material form:
- liquid
- Details on test material:
- - Name of test material :1-Methylpiperazine
- Molecular formula :C5H12N2
- Molecular weight:100.1638 g/mole
- Substance type:Organic
- Smiles notation: N1(CCNCC1)C
- InChl: 1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material :1-Methylpiperazine
- Molecular formula :C5H12N2
- Molecular weight:100.1638 g/mole
- Substance type:Organic
- Smiles notation: N1(CCNCC1)C
- InChl: 1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- other: Unchanged or solutions in water, propylene glycol, or acetone.
- Controls:
- not specified
- Amount / concentration applied:
- Amount:0.01ml
concentration applied:100%
or
0.01ml of 1-methylpiperazine solutions in water, propylene glycol, or acetone - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- 5
- Details on study design:
- - Area of exposure: belly of each rabbit
-SCORING SYSTEM: Primary skin irritation on rabbits was recorded in a 10-grade ordinal series and was based upon the severest reaction that developed on the clipped skin of each of five albino rabbits. Grade 1 in indicated no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 6
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Necrosis of skin was observed in treated rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Primary skin Irritation score for 1-methylpiperazine (CAS No: 109-01-3) was Grade 6. Based on the grade, 1-methylpiperazine (CAS No: 109-01-3) was considered to be irritating to the skin of albino rabbits
- Executive summary:
The skin irritation test was conducted on five rabbits’ belly to assess the degree of skin irritation of test chemical 1-methylpiperazine (CAS No: 109-01-3).
Each rabbits received 0.1mlof undiluted1-methylpiperazineor of solutions in water, propylene glycol, or acetoneon clipped belly skin for 24 hour under uncovered condition.
Primary skin irritation on rabbits was recorded in a 10-grade ordinal series and was based upon the severest reaction that developed on the clipped skin of each of five albino rabbits.
Grade 1 in indicated no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution.
The primary skin Irritation score for1-methylpiperazine (CAS No: 109-01-3)was observed to be Grade 6 indicatingNecrosis of skin in treated rabbits. Thusbased on the grade, 1-methylpiperazine (CAS No: 109-01-3)was considered to be irritating to the skin of albino rabbits.
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