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EC number: 209-843-0 | CAS number: 594-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006 - 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Ethanesulphonic acid
- EC Number:
- 209-843-0
- EC Name:
- Ethanesulphonic acid
- Cas Number:
- 594-45-6
- Molecular formula:
- C2H6O3S
- IUPAC Name:
- ethanesulfonic acid
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:WI(Han), SPF quality
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 50 mg/kg:
300 mg/kg
2000 mg/kg - No. of animals per sex per dose:
- 50 mg/kg: 3 females
300 mg/kg: 3 females / 3 males
2000 mg/kg: 3 females - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- In rats, no mortality was observed subsequent to a single oral administration of 50 mg/kg
in females or 300 mg/kg in rats of both genders.
Following administration of 2000 mg/kg to female rats, No. 352 was found dead on Day 1
(6.0 h post administration), and No. 351 in the morning of Day 2. Female No. 353 survived
the entire observation period. - Clinical signs:
- 50 mg/kg (females only)
No clinical signs were recorded.
300 mg/kg (males and females)
Clinical signs were observed in males on Day 1 only and included piloerection (0.5 h to
8.0 h post administration) and reduced motor activity (0.5 h to 2.0 h post administration).
All males returned to normal on Day 2 and no further clinical signs were observed
throughout the entire observation period.
2000 mg/kg (females only)
Clinical signs were observed throughout Day 1 in all animals and included piloerection
and reduced motor activity. In addition, prone position and decreased breathing rate
(0.25 h to 0.5 h post administration) was recorded temporarily on Day 1. The latter
decedent No. 351 appeared cold to the touch (8.0 h to 10.5 h). The surviving female
No. 353 returned to normal in the morning of Day 2 and no further clinical signs were
observed throughout the entire observation period - Body weight:
- At 50 mg/kg and at 300 mg/kg, no influence on body weight development was observed.
Compared to rats administered the latter doses, a reduced body weight was recorded on
Day 2 in rat No. 353, the single out of three females surviving administration of
2000 mg/kg. This difference was no longer obvious on Day 8 and Day 15. - Gross pathology:
- No necropsy findings were recorded subsequent to a single oral administration of
50 mg/kg or 300 mg/kg.
Necropsy findings in No. 351 and No. 352, the two premature decedents at 2000 mg/kg,
included stasis of liver, spleen and kidneys, an altered content of the abdomen, as well as
alterations in the stomach and the intestine.
No necropsy findings were recorded for No. 353, the single female surviving the entire
observation period following administration of the latter dose.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of the present study, no mortality was seen in rats subsequent to a
single oral administration of ethane sulfonic acid doses of 50 mg/kg and 300 mg/kg,
respectively. Following an administration of 2000 mg/kg, two out of three females died.
Thus, at the given purity of 70%, the approximate lethal dose (ALD) for ethane sulfonic
acid is between 300 mg/kg and 2000 mg/kg for
male and female rats
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