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Diss Factsheets
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EC number: 217-442-7 | CAS number: 1852-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish, juvenile growth test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- See the Analogue Approach Report attached in Section 13 of the IUCLID dossier.
- Reason / purpose for cross-reference:
- other: Read across to target substance
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A 28-day study was conducted to determine the toxicity of acrylamide monomer to carp (Cyprinus carpio).
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- yes
- Details on test solutions:
- Dechlorinated municipal tap water
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: carp
- Strain: Cyprinus carpio
- Source: The carp fingerl ings used in the test were selected from an in-house culture.
- Mean weight: 3.04 g +/- 0.73 g
- Type/source of feed: Tetra SM 80 flake food and Glencoe #3 fish pellets
- Amount given: ad-lib basis
- Frequency of feeding: daily
: - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Post exposure observation period:
- No
- Hardness:
- No data
- Test temperature:
- 13°C (*+/-1°).
- pH:
- No data
- Dissolved oxygen:
- No data
- Nominal and measured concentrations:
- Nominal exposure concentrations were 0, 50, 500 and 5000 µg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material: 20 litre all-glass aquaria containing 15.5 litres
- Aeration: Constant aeration
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per vehicle control (replicates): 2
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 12-hour daylight
EFFECT PARAMETERS MEASURED: toxicity
VEHICLE CONTROL PERFORMED: yes
- Reference substance (positive control):
- no
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 5 000 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- and behavior
- Details on results:
- Acrylamide did not produce any mortality or observed behavior modification at any concentration.
- Validity criteria fulfilled:
- yes
- Conclusions:
- No mortalities or behavioural modifications were noted during the course of the study. The No Observed Effect Level was the highest exposure concentration of 5 mg/l.
Reference
Description of key information
A 28-day study was conducted to determine the long-term toxicity of the read-across material, acrylamide, to carp (Cyprinus carpio) in a static freshwater test. The No Observed Effect Level was the highest exposure concentration of 5 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5 mg/L
Additional information
The long term toxicity to fish of the read-across substance, acrylamide, was assessed in a juvenile growth test in carp (Cyprinus carpio) in a static freshwater study for 28 days at nominal exposure concentrations of 0, 50, 500 and 5000 µg/L.
Two sets of 4 all-glass aquaria containing 15.5 litres of dechlorinated municipal tap water were immersed in a water bath held at 13 ± 1 °C. Constant aeration was maintained in each aquarium containing test fish. The fish were introduced into one series of four aquaria immediately after the addition of the assigned concentration of the acrylamide monomer solution. Water changes were accomplished by transferring the test fish between the two sets of four aquaria. The test fish were fed Tetra SM 80 flake food upon introduction to the test system and then prior to each transfer. The temperature of the water-bath was recorded daily.
The read-across substance, acrylamide, did not produce any mortality or observed behaviour modification at any concentration during the study. The No Observed Effect Level was the highest exposure concentration of 5000 µg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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