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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14/8/2013 to 25/4/2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
14 mg/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
>= 6.54 - <= 6.66

Table 1 Results from definitive water solubility study

Sample number

Time shaken at 30°C (Hours)

Time equilibrated at 20°C (Hours)

Concentration (mg/L)

pH after test

Sample 1A

24

24

15

6.66

Sample 1B

24

24

14

6.54

Sample 2A

48

24

14

6.59

Sample 2B

48

24

14

6.62

Sample 3A

72

24

14

6.64

Sample 3B

72

24

14

6.61

Conclusions:
The water solubility of the test item was determined to be 14 mg/L at 20°C.
Executive summary:

The water solubility of the item was determined by using the Flask method of OECD TG 105. The amount of test item dissolved in water was determined by HPLC analysis with PDA detection. The water solubility was determined to be 14 mg/L at 20°C.

The study is reliable without restrictions (Klimisch 1), having followed a standard guideline.

Description of key information

The water solubility of the test item was determined to be 14 mg/L at 20°C.

Key value for chemical safety assessment

Water solubility:
14 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the item was determined by using the Flask method of OECD TG 105 (2014). The amount of test item dissolved in water was determined by HPLC analysis with PDA detection. The water solubility was determined to be 14 mg/L at 20°C.

The study is reliable without restrictions (Klimisch 1), having followed a standard guideline.