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Diss Factsheets
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EC number: 203-656-8 | CAS number: 109-21-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-02-06 to 2017-02-10
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 628 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1 830 mg/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- Remarks on result:
- other: Mean of 6 measurements, 2 at each sampling time 24, 48 and 72h
- Conclusions:
- The test item was found to have a water solubility of 627.8 mg/L at 20°C and a pH of 6.
- Executive summary:
The water solubility of the test substance was determined according to OECD test guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6.
The solubility of the test substance was determined using the flask method at 20 +- 0.5 °C with pre-incubation at 30 +- 0.5°C. Measurements were performed after 24, 48 and 72h.
The water solubility of the test substance was determined to be 627.8 mg/L (20°C, pH 6).
Reference
1. Preliminary test (non-GLP):
The determination solubility in double distilled water was 366 mg/L. For the application dose for the definitive study, 1.8 g/L, as ca. the fivefold of the maximum solubility result, was used.
2. Water solubility results;
Water solubility has been measured at 20°C and pH: 6
Preincubation time | Replicate No. | Test substance concentration (mg/L) |
24 h | 1 | 647.1 |
2 | 631.1 | |
48h | 1 | 643.4 |
2 | 617.3 | |
72h | 1 | 617.4 |
2 | 610.6 | |
Mean (24-72h) | 627.8 | |
Deviation (%) (24-72h) | 6.0 |
Validity Criteria:
- Repeatability: The concentration measured in at least the samples with the two longest incubation times (48 and 72h) should not differ by more than 15%.
- Temperatures: Temperatures should be kept constant within +- 0.5°C
- Linearity: regression coefficient of calibration curve: 1.0000
- Specificity: no interference of the total area for target analyte was observed
- Accuracy: the mean recovery values of samples fortified with the analyte was determined to be 95%
- Precision: the relative standard deviation of repeated analysis of 5 independent fortification samples was 4.3%
- Repeatability of injection: one standard solution was injected 5 times. The relative standard deviation was 0.9%.
Description of key information
For this endpoint the water solubility has been determined experimentally according to OECD 105, flask method and GLP. The test item was found to have a water solubility of 627.8 mg/L at 20°C and a pH of 6.
Key value for chemical safety assessment
- Water solubility:
- 627.8 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.