Registration Dossier
Registration Dossier
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EC number: 431-870-3 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 Nov 1999 - 26 Nov 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under OECD method and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC Directive 92/69/EEC, Part C, Method C2
- GLP compliance:
- yes
Test material
Constituent 1
Test solutions
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: Direct addition of test substance to diluent water with ultrasonication to aid dispersion.
Test organisms
- Test organisms (species):
- Daphnia magna
Test conditions
- Hardness:
- 250 mg CaCO3/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 43 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 29 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 43 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.91 mg/L
Applicant's summary and conclusion
- Conclusions:
- The 48 Hour EC50 (immoblisation) value with Daphnia Magna was determined to be 29mg/l.
The "No-observed effect concentration" (NOEC) was 0.91mg/l - Executive summary:
In a 48h acute aquatic toxicity test on Daphnia magna, the LC50 value for the test substance BMS 217947 -01, was 29 mg/l. The NOEC was 0.91 mg/l.
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