Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-224-6 | CAS number: 6974-77-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-11-22 to 1995-3-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- other: EPA (TSCA) Pesticide Assessment Guidelines
- Version / remarks:
- 1985
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-bromo-3-chloro-2-methylpropane
- EC Number:
- 230-224-6
- EC Name:
- 1-bromo-3-chloro-2-methylpropane
- Cas Number:
- 6974-77-2
- Molecular formula:
- C4H8BrCl
- IUPAC Name:
- 1-bromo-3-chloro-2-methylpropane
Constituent 1
- Specific details on test material used for the study:
- Batch NO. 48241
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited.
- Housing: Stainless steel cages mounted in mobile batteries. The cages were fitted with perforated counter-sink floor pannels. A tray beneath the floor was line with absorbent paper which was chnaged regularly.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: not kbown
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18C (15 - 23C)
- Humidity (%): 55 %R.H. (40 - 70% R.H.)
- Air changes (per hr): at least 10 times per hours
- Photoperiod (hrs dark / hrs light): 12 hrs dark/ 12 hrs light
IN-LIFE DATES: From: To: Day 14 after treatment
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- amount applied : 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after removal of badages.
Additional observations of persistent effects of treatment were made on Days 7, 10 and 13.
The reaction of the test sites were assessed according to the criteria of Draize. - Number of animals:
- 6 male rabbits
- Details on study design:
- Each rabbit was securely restrained by a technician. Two test sites (6 x 6 cm) were marked on either side of the clipped area of dorsum. A single dose was applied directly to the skin and covered by an unmedicated gauze patch (3 x 2 cm) which was held in place on the left test site by strips of Blenderm (Community Care products, 3M Health Care, Loughborough, England). The right test site, acting as a control, was covered by a similar semi-occlusive dressing but otherwise remained untreated. Pads of cotton wool and elasticated bandage were used to protect the patches and ensure good contact between the skin and test material during the four-hour exposure period.
The dressings were removed after four hours exposure; the treatment sites were gently washed with warm water and dried with paper tissues to remove excess test material adheringto the skin.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 h after removal of dressing
- Score:
- 1.8
- Max. score:
- 2
- Reversibility:
- fully reversible within: 10 dats
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0.2
- Max. score:
- 1
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 10 d
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 13 days
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 hour after removal
- Score:
- 1.5
- Max. score:
- 2
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0.8
- Max. score:
- 1
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 10 d
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 13 days
- Score:
- 0
- Irritant / corrosive response data:
- During the first hour following bandage removal, well-defined erythema was observed in five rabbits and very slight erythema in one. Slight edima was observed was observed in three rabbits and very slight edema in three rabbits at this time. At the 24, 48, and 72 hour examinations, very slight erythema and very slight edema were observed in all rabbits.
On Day 7, one rabbit showed very slight erythema and edema and four rabbits showed very slight edema. On Day 10, very slight edema persisted in four of these rabbits.
The test site of one rabbit was overtly normal on Day 7, another Day 10 and the remaining four animals on Day 13.
The control sites did not show any response to the control procedure.
Any other information on results incl. tables
Scoring of irritance responses
Test site: 0.5 ml 2-MBCP Control site: No treatment
Semi-occluded for four hours
Animal No. and sex |
Type of Response |
Score after removal of dressing |
|||||||
1 hour |
24 hours |
48 hours |
72 hours |
||||||
Test site |
Control site |
Test site |
Control site |
Test site |
Control site |
Test site |
Control site |
||
32TD 602M |
Erythema |
2 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
Edema |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
|
32TD 605M |
Erythema |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
Edema |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
|
32TD 612M |
Erythema |
2 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
Edema |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
|
32TD 617M |
Erythema |
2 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
Edema |
2 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
|
32TD 619M |
Erythema |
2 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
Edema |
2 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
|
32TD 620M |
Erythema |
2 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
Edema |
2 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
Animal No. and sex |
Type of Response |
Score after removal of dressing |
|||||
Day 7 |
Day 10 |
Day 13 |
|||||
Test site |
Control site |
Test site |
Control site |
Test site |
Control site |
||
32TD 602M |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
Edema |
1 |
0 |
1 |
0 |
0 |
0 |
|
32TD 605M |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
Edema |
0 |
0 |
0 |
0 |
0 |
0 |
|
32TD 612M |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
Edema |
1 |
0 |
1 |
0 |
0 |
0 |
|
32TD 617M |
Erythema |
1 |
0 |
0 |
0 |
0 |
0 |
Edema |
1 |
0 |
1 |
0 |
0 |
0 |
|
32TD 619M |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
Edema |
1 |
0 |
1 |
0 |
0 |
0 |
|
32TD 620M |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
Edema |
1 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under test conditions of this test, 1-bromo-3-chloro-2-methylpropane was considered to be "slightly irritant" to skin.
This result does not met GHS criteria for skin irritation. - Executive summary:
Under test conditions of this test, 1-bromo-3-chloro-2-methylpropane was considered to be "slightly irritant" to skin.
This result does not met GHS criteria for skin irritation. This substance is not irritate to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.