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EC number: 617-648-0 | CAS number: 849727-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-06-02 to 2003-006-25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study followed OECD guideline 423 (Acute Oral Toxicity-Acute Toxic Class Method), however, the test substance is not adequately characterized and insufficient information is provided on the test animals.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- modified on 2001-12-17
- Deviations:
- yes
- Remarks:
- : 1) no characterization of the test material; 2) not sufficient data for the animals tested.
- Principles of method if other than guideline:
- Study is performed according to SPL Standard Method 520.01
- GLP compliance:
- no
- Remarks:
- The study was conducted in a facility operating to Good Laboratory Practice within the UK national GLP monitoring programme, but the study report had not been audited by the QA Unit. No formal claim of GLP compliance was made for the study.
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE HYDROCHLORIDE (1:1)
- EC Number:
- 617-648-0
- Cas Number:
- 849727-62-4
- Molecular formula:
- C11H11ClN2O2.HCl
- IUPAC Name:
- 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE HYDROCHLORIDE (1:1)
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 28-38 g
- Fasting period before study: Yes, no further data provided
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE: no data
MAXIMUM DOSE VOLUME APPLIED:
- no data
DOSAGE PREPARATION (if unusual):
- no data
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: advised in OECD-423 guideline - Doses:
- 300 mg/kg bw (two groups); 2000 mg/kg bw stepwise procedure
- No. of animals per sex per dose:
- 3 females/group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: mortality and clinical signs were observed 30 minutes, 1, 2, and 4 hours after dosing, and daily for 14 days after dosing. Body weights were recorded on days 0, 7, and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: mortality, clinical signs, body weight, and macroscopic examinations.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 500 mg/kg bw
- Mortality:
- All animals treated at a dose level of 2000 mg/kg bw were found dead one or two hours after dosing. There were no deaths noted in animals treated at a dose level of 300 mg/kg bw.
- Clinical signs:
- other: The animals treated with 2000 mg/kg bw, had hunched posture, lethargy, ataxia, decreased respiratory rate, and laboured respiration. No clinical signs were observed in animals treated at 300 mg/kg bw.
- Body weight:
- other body weight observations
- Remarks:
- The bodyweight was within the normal range of variability.
- Gross pathology:
- The animals treated with 300 mg/kg bw had no abnormalities observed during necropsy. At 2000 mg/kg dose level, haemorrhagic lungs, dark liver, dark kidneys, and haemorrhagic gastric mucosa were observed in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 of the test substance in female CD-1 strain mouse was estimated to be in the range of 300-500 mg/kg bodyweight. However, based on expert judgement it is concluded that since only 300 and 2000 mg/kg were tested in this study, it cannot be estimated that the LD50 will be situated in the range 300 - 500 mg/kg according to the guidelines.
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