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Diss Factsheets
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EC number: 201-557-4 | CAS number: 84-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
- Endpoint:
- toxicity to birds, other
- Remarks:
- short-term: effects on eggs
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- No guideline specified, cf. "Any other information on material and methods" for details.
- GLP compliance:
- not specified
Test material
- Specific details on test material used for the study:
- Phthalates were kindly provided by the Monsanto Chemical Company.
- Dose method:
- feed
Test organisms
- Test organisms (species):
- other: Streptopelia risoria
Study design
- Total exposure duration (if not single dose):
- 48 h
- Control animals:
- yes
Results and discussion
Any other information on results incl. tables
The most significant findings were that eggshell thickness was decreased and permeability to water increased by a diet containing 10 ppm d-n-butyl phthalate (Table 1). In contrast, no significant effect
was found with di-2-ethylhexyl phthalate. The rate of water loss increased by 23% whereas the decrease in eggshell thickness was only 10%. It was noted that small dents occurred rather frequently
in eggs from birds treated with DNBP. While damaged eggs were excluded from those used for the calculation of water loss and permeability, micro-damage to the eggshell may have been the cause of'
increased water loss. The experiments on the breaking strength of the egg were unsatisfactory, due to the fact that the low values (0.5-1.0 lb) are at the low end of the range of the Instron Testing machine used. Damage to the surface, rather than hairline cracks, was observed and breaking strength correlated poorly with shell index. Structurally, the main differences appear to be the presence of more fibrous materials in the eggshell (Figure 1) compared to control eggs. The size and distribution of pores appear-to be unaffected despite the considerable increase in permeability. The effect of DNBP thus has considerable differences from DDE where decreased numbers of pores are observed (PEAKALL et al. 1973), permeability is decreased, and cracking is more common than denting.
Applicant's summary and conclusion
- Conclusions:
- Eggshell thickness was decreased and permeability to water increased by a diet containing 10 ppm d-n-butyl phthalate.
- Executive summary:
In this study the effects of a diet of 10 ppm DNBP and 10 ppm DEHP on eggshell thickness, breaking strength, permeability, and shell structure of the eggs of Ring Doves
(Streptopelia risoria) were examined.
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