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EC number: 413-800-3 | CAS number: 87787-81-3 STEPAN TAB -2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 19, `990 to March 6, 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was run by a method similar to a guideline study, but specific guideline number was not designated. Sample purity was note noted. GLP was followed.
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA FIFRA and TSCA guidelines specified in 40 CFR 158, 162 , and OECD Guidelines. Specific guidelines not specified.
- Deviations:
- no
- Remarks:
- Report stated that no deviations occurred.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 87787-81-3
- EC Number:
- 618-070-1
- Cas Number:
- 87787-81-3
- IUPAC Name:
- 87787-81-3
- Reference substance name:
- A mixture of: N,N-di(hydrogenated alkyl C14-C18)phthalamic acid; dihydrogenated alkyl (C14-C18)amine
- EC Number:
- 413-800-3
- EC Name:
- A mixture of: N,N-di(hydrogenated alkyl C14-C18)phthalamic acid; dihydrogenated alkyl (C14-C18)amine
- Cas Number:
- 87787-81-3
- Molecular formula:
- C44H79NO3
- IUPAC Name:
- 2-(dioctadecylcarbamoyl)benzoic acid; 2-(ditetradecylcarbamoyl)benzoic acid; 2-[(propan-2-yloxy)carbonyl]benzoic acid; 2-[octadecyl(tetradecyl)carbamoyl]benzoic acid; 2-octadecyl-2,3-dihydro-1H-isoindole-1,3-dione; 2-tetradecyl-2,3-dihydro-1H-isoindole-1,3-dione; benzene-1,2-dicarboxylic acid; dioctadecylamine; ditetradecylamine; octadecyl(tetradecyl)amine
- Reference substance name:
- reaction mass of: N,N-di(hydrogenated alkyl C14-C18)phthalamic acid dihydrogenated alkyl (C14-C18)amine
- IUPAC Name:
- reaction mass of: N,N-di(hydrogenated alkyl C14-C18)phthalamic acid dihydrogenated alkyl (C14-C18)amine
- Reference substance name:
- Stepan TAB-2
- IUPAC Name:
- Stepan TAB-2
- Details on test material:
- No data on test substance purity or composition. It is assumed to be typical commercial material. Test material designation is as Stepan Agent X1401-91. Test substance was stored at room temperature in a clear colorless glass jar with a black plastic lid..
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino Sprague-Dawley rats, weighing between 227 and 332 grams at the start of the study. All animals were acclimated to the laboratory for at least four days before the study. Animals are usually housed five per cage in wire mesh suspension cages and fed Purina Laboratory Chow or other complete diet, and tap water ad libitum except overnight prior to dosing. The animals were obtained on a 12-hour light/12-hour dark cycle. Each rat were individually numbered via ear tags and ink marks on the tail. Overnight prior to dosing, food (but not water) was withheld from the rats. The time of fast initiation and the time of dosing was documented.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test material was administered as a 25% w/v formulation in corn oil to five male and five female rats at a dose level of 5.0 g/kg/bw. Test material was administered by esophageal intubation..
- Doses:
- 5.0 mg/kg/bw as 25% in corn oil.
- No. of animals per sex per dose:
- five per sex per dose
- Control animals:
- no
- Details on study design:
- A group of ten rats (five per sex) were dosed by gavage with 5 g/kg dose level (25% in corn oil) by gavage. All animals were observed for gross signs of systemic toxicity and mortality several times during the day of dosing, and at least twice daily for a total of 14 days. Observations were documented. Animals were observed more often if animals exhibited definite signs of toxicity. Animals were weighed on the day of dosing and at death. Survivors were weighed 7 and 14 days after treatment. Gross necropsy was performed on any animal which died, and observations were documented. At the end of the 14-day observation period after dosing, each surviving rat was sacrificed, and a gross necropsy was performed. The terminal weight and appropriate observations were documented for each rat.
- Statistics:
- No data.
Results and discussion
- Preliminary study:
- No preliminary study performed.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality was observed in any of the ten animals tested.
- Clinical signs:
- other: Aside from a red stain on an unspecified number of female rats, and scruffy or oily hair noted for several male rats, no signs of stress or pain were noted. Behavior of animals was normal.
- Gross pathology:
- Gross necropsy was performed on all animals upon sacrifice.
- Other findings:
- No other findings.
Any other information on results incl. tables
Table 1: Body Weight Data in Male and Female Rats Treated Orally with a 25% w/v Formulation of Stepan Agent x1401-91 in Corn Oil
|
|
Body Weight (g) |
|
||
Animal No. |
Sex |
Day 0 |
Day 7 |
Day 14 |
Body weight Change Day 0-14 (g) |
1-0863 |
M |
309 |
369 |
387 |
78 |
2-* |
M |
325 |
378 |
401 |
76 |
3-0865 |
M |
314 |
363 |
394 |
80 |
4-0866 |
M |
332 |
396 |
429 |
97 |
5 - * |
M |
283 |
339 |
361 |
78 |
Mean (S.D.) |
|
313 (19) |
369 (21) |
394 (25) |
82 (9) |
|
|
|
|
|
|
6 - * |
F |
237 |
259 |
275 |
38 |
7 - * |
F |
244 |
281 |
291 |
47 |
8 - * |
F |
271 |
294 |
288 |
17 |
9 - * |
F |
227 |
252 |
259 |
32 |
10-0872 |
F |
241 |
269 |
281 |
40 |
Mean (S.D.) |
|
244 (16) |
271 (17) |
279 (13) |
35 (11) |
· = Lost ear tag prior to dosing.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: US EPA pesticides
- Conclusions:
- The acute oral LD50 for Stepan TAB-2 was found to be >5.0 g/kg in male and female sprague-Dawley rats.
- Executive summary:
A standard acute oral toxicity study was conducted for Stepan TAB-2 (designated as Stepan Agent x1401 -91) by the oral gavage route. The test material was administered as a limit dose of 5 g/kg body weight (25% in corn oil). Five male and five female rats constituted the dosed group. Body weights and clinical observations were recorded.. No mortality was observed over the 14 day post dosing observation period and all ten animals survived. Aside from a red stain on muzzle of one rat, and scruffy or oily hair noted, no signs of stress or pain were noted. Behavior of animals was normal. The acute oral LD50 for Stepan TAB-2 was found to be >5.0 g/kg in male and female rats, sprague-Dawley rats.
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