Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 271-816-4 | CAS number: 68609-04-1 The complex combination of hydrocarbons produced by the distillation of products from the air oxidation of cyclohexane after removal of acidic materials. It consists of hydrocarbons having carbon numbers predominantly in the range of C6 through C12 and boiling in the range of approximately 172°C to 324°C (342°F to 615°F).
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only 8 days observation period
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexane, oxidized, non-acidic by-products, distn. residues
- EC Number:
- 271-816-4
- EC Name:
- Cyclohexane, oxidized, non-acidic by-products, distn. residues
- Cas Number:
- 68609-04-1
- IUPAC Name:
- (1s,4s)-cyclohexane-1,4-diol (cyclohexyloxy)cyclohexane 2-butylcyclohexan-1-one 8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7)-diene cyclohexane cyclohexane-1,3-diol cyclohexanol phenol hydrate
- Details on test material:
- - Name of test material (as cited in study report): Anone destillation residue
- Analytical purity: not reported
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach
- Mean weight at study initiation: male 2.79 Kg, female 2.65 Kg
- Housing: single
- Diet: Kliba 341 (about 130 g/animal/day)
- Water: 250 ml tap water/animal/day
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml undiluted - Duration of treatment / exposure:
- kept unwashed
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: Draize scoring
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: see table in free text for individual score
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72 h
- Score:
- 0.2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: see table in free text for individual score
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72 h
- Score:
- 1.6
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: see table in free text for individual score
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72 h
- Score:
- 0.2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: see table in free text for individual score
Any other information on results incl. tables
Readings |
Animal No. |
Cornea |
Iris |
Conjunctivae |
Chemosis |
Symptoms |
1 h |
1 |
0 |
0 |
2 |
1 |
|
2 |
0 |
0 |
2 |
1 |
|
|
3 |
0 |
0 |
2 |
1 |
|
|
24 h |
1 |
1 |
1 |
2 |
1 |
PC/RE |
2 |
1 |
0 |
2 |
0 |
PC/RE |
|
3 |
1 |
1 |
2 |
1 |
PC/RE |
|
48 h |
1 |
1 |
0 |
2 |
0 |
PC/RE |
2 |
1 |
0 |
2 |
0 |
PC/RE |
|
3 |
1 |
0 |
1 |
0 |
PC/RE |
|
72 h |
1 |
1 |
0 |
1 |
0 |
RE |
2 |
1 |
0 |
1 |
0 |
RE/PC |
|
3 |
1 |
0 |
1 |
0 |
RE/PC/MV/LC |
|
8 d |
1 |
0 |
0 |
0 |
0 |
RE |
2 |
0 |
0 |
0 |
0 |
RE |
|
3 |
0 |
0 |
0 |
0 |
RE/MV |
|
Mean (24-48-72 h) |
1 |
1.0 |
0.3 |
1.7 |
0.3 |
|
2 |
1.0 |
0.0 |
1.7 |
0.0 |
|
|
3 |
1.0 |
0.3 |
1.3 |
0.3 |
|
|
Mean |
|
1.0 |
0.2 |
1.6 |
0.2 |
|
PC - pupil contracted
RE - small retractions in the eyelids
MV - marginal vascularization of the cornea
LC - loss of corneal tissue
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
