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EC number: 202-068-9 | CAS number: 91-44-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as-
2. and 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Estimation method (if used):
- 2. no data available
3. Structure estimation method - Duration:
- 20 d
- Remarks:
- 2. The study was performedat pH range7.4 to 7.8 & 20.1 to 20.5⁰C, respectively. Test chemical conc. measuredwere 0.0287, 0.0320, 0.0334, 0.0349, 0.0251, 0.0311, 0.0414, 0.0370, 0.0362 & 0.0363 mg/l at 0, 1, 3, 6, 8, 10, 13, 15, 17 & 20 days, respectively.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Key result
- Remarks on result:
- other: 2. Although half-life value of chemical was not known, but based on the measured concentration of test chemical in water, chemical appears to be in equilibrium and does not appear to be breaking down in water.
- pH:
- 7
- DT50:
- 1.4 yr
- Type:
- second order
- Remarks on result:
- other: 3. Hydrolysis rate constant is 0.16 L/mol-sec.
- pH:
- 8
- DT50:
- 51 d
- Type:
- second order
- Remarks on result:
- other: 3. Hydrolysis rate constant is 0.16 L/mol-sec.
- Details on results:
- 2. Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from > 20 days to 1.4 yr, at pH range 7-8 & temperature of 20.1-20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
- Executive summary:
Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performedat apH range7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively.The test substance was dissolved in dechlorinated tap water. The concentration of the test substance was measured in the supernatant of the test solution centrifuged. The test substance was measured on day 0, 1, 3, 6, 8, 10, 13, 15, 17, and 20 over a 21-day period. The test concentration used was considered to be at saturation in water. Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time. Thus, the half-life value of test chemical was determined to be > 20 days and on the basis of this, test chemical is considered to be not hydrolysable.
In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from > 20 days to 1.4 yr, at pH range 7-8 & temperature of 20.1-20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Reference
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from > 20 days to 1.4 yr, at pH range 7-8 & temperature of 20.1-20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 20 d
- at the temperature of:
- 20.5 °C
Additional information
Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed at a pH range7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. The test substance was dissolved in dechlorinated tap water. The concentration of the test substance was measured in the supernatant of the test solution centrifuged. The test substance was measured on day 0, 1, 3, 6, 8, 10, 13, 15, 17, and 20 over a 21-day period. The test concentration used was considered to be at saturation in water. Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time. Thus, the half-life value of test chemical was determined to be > 20 days and on the basis of this, test chemical is considered to be not hydrolysable.
In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from > 20 days to 1.4 yr, at pH range 7-8 & temperature of 20.1-20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
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