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Diss Factsheets
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EC number: 202-039-0 | CAS number: 91-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Static 96 h toxicity tests were performed with one freshwater species Pimephales promelas to determine influenced to aquatic toxicities.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant):deionized water or acetone - Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name:Fathead minnow
- Source:EPA Newtown Fish Toxicology Station, Cincinnati, Ohio
- Length at study initiation (length definition, mean, range and SD):3.2 to 4.2 cm
- Food type:ration of Tetra SM
- Frequency:twice daily
ACCLIMATION
- Acclimation period:4 days
- Acclimation conditions (same as test or not):The minnows were acclimated to the test dilution water quality and temperature over the first two days of a fourday acclimation period. Solution withdrawal and renewal twice daily accomplished the water quality transition and temperature was reduced from 25 ° to 22°C with the aid of a temperature bath-circulator. The fish were held for the last two days of acclimation at 22°C in 100% dilution water.
- Type and amount of food:ration of Tetra SM
- Feeding frequency:no food was given during the four-day period
- Health during acclimation (any mortality observed):The fish were observed for a minimum of 14 days (at least 10 days after any disease treatment) before being acclimated for testing. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 40-48 mg/l as CaCO3
- Test temperature:
- 22°C
- pH:
- 7.2-7.9
- Dissolved oxygen:
- No data
- Salinity:
- alkalinity, 30-35 mg/l as CaCO3
- Nominal and measured concentrations:
- 5 nominal concentration was used.
- Details on test conditions:
- TEST SYSTEM
- Test vessel:distilled water bottles with the necks removed
- Type (delete if not applicable): open
- No. of organisms per vessel:10
- No. of vessels per concentration (replicates):2
- No. of vessels per control (replicates):2
- Biomass loading rate:The loading of organisms per liter of dilution water was less than 0.8g1-1 in all cases.
OTHER TEST CONDITIONS
- Adjustment of pH:no
- Photoperiod:16h light-8 h dark diurnal cycle - Reference substance (positive control):
- not specified
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 195 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 143.8-278.6
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 172 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 118.1-250.4
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 164 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 108.8-240.4
- Details on results:
- During the 96 h test period, deaths were recorded and bodies removed when noticed. Per cent survival, dissolved oxygen, and temperature were determined in each aquaria every 24 h.
- Reported statistics and error estimates:
- LC50's and confidence intervals were determined by either probit analysis (Finney, 1971; Barr et al., 1976), moving average method, or the binomial test (Stephan, 1977), depending on the number of partial kills observed. Each confidence interval describes the distribution of sensitivities of the test organisms: it does not indicate the precision of the acute mortality test.
- Sublethal observations / clinical signs:
Solvent and recovery efficiencies for the detection of test compound in aqueous mixture:
Compound
Solvent
No. of trials
Mean %recovery
Std.deviation
Toluene-2,4-diisocyanat e
Benzene
5
89.6
2.0
- Validity criteria fulfilled:
- yes
- Conclusions:
- Toluene-2,4-diisocyanate was not found to be hazardous to freshwater fish Pimephales promelas with lethal concentration (LC50)195 mg/L for 24 hr; 172 mg/L for 48 hr; 164 mg/L for exposure period 96 hrs.
- Executive summary:
Static 96 h toxicity tests were performed with one freshwater species Pimephales promelas (Fathead minnow)to determine influenced to aquatic toxicities.
For analytical analysis Model 2100 gas chromatograph equipped with electron capture detector and column of 3~ SE-30 on 100/120 Vataport 30 was used.and deionized water or acetone used as a vehicle.LC50's and confidence intervals were determined by either probit analysis (Finney, 1971; Barr et al., 1976), moving average method, or the binomial test (Stephan, 1977), depending on the number of partial kills observed. Each confidence interval describes the distribution of sensitivities of the test organisms: it does not indicate the precision of the acute mortality test.
LC50's and confidence intervals were determined by either probit analysis (Finney, 1971; Barr et al., 1976), moving average method, or the binomial test (Stephan, 1977), depending on the number of partial kills observed. Each confidence interval describes the distribution of sensitivities of the test organisms: it does not indicate the precision of the acute mortality test.
From experimetal result ot is concluded that the Toluene-2,4-diisocyanate was not found to be hazardous to freshwater fish Pimephales promelas with lethal concentration (LC50)195 mg/L for 24 hr; 172 mg/L for 48 hr; 164 mg/L for exposure period 96 hrs.
Reference
Description of key information
Toluene-2,4-diisocyanate was not found to be hazardous to freshwater fish Pimephales promelas with lethal concentration (LC50)195 mg/L for 24 hr; 172 mg/L for 48 hr; 164 mg/L for exposure period 96 hrs.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 164 mg/L
Additional information
Static 96 h toxicity tests were performed with one freshwater species Pimephales promelas (Fathead minnow)to determine influenced to aquatic toxicities.
For analytical analysis Model 2100 gas chromatograph equipped with electron capture detector and column of 3~ SE-30 on 100/120 Vataport 30 was used.and deionized water or acetone used as a vehicle.LC50's and confidence intervals were determined by either probit analysis (Finney, 1971; Barr et al., 1976), moving average method, or the binomial test (Stephan, 1977), depending on the number of partial kills observed. Each confidence interval describes the distribution of sensitivities of the test organisms: it does not indicate the precision of the acute mortality test.
LC50's and confidence intervals were determined by either probit analysis (Finney, 1971; Barr et al., 1976), moving average method, or the binomial test (Stephan, 1977), depending on the number of partial kills observed. Each confidence interval describes the distribution of sensitivities of the test organisms: it does not indicate the precision of the acute mortality test.
From experimetal result ot is concluded that the Toluene-2,4-diisocyanate was not found to be hazardous to freshwater fish Pimephales promelas with lethal concentration (LC50)195 mg/L for 24 hr; 172 mg/L for 48 hr; 164 mg/L for exposure period 96 hrs.
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