Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across from an analogue substance for which a guideline study (Klimisch 2) is available.
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across approach from data on an analogue substance.
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- -1.5
- Temp.:
- 25 °C
- Remarks on result:
- other: Strongest pKa(Acid)
- No.:
- #2
- pKa:
- 3.3
- Temp.:
- 25 °C
- Remarks on result:
- other: Strongest pKa(Base):
- Conclusions:
- Based on data on an analogue substance, the Dissociation constant for the substance defined in this dossier is estimated to be coincident to the analogue described: -1.5 ± 0.5 at 25°C for the sulfonate groups and 3.3 ± 1.4 at 25°C for the triazinyl groups.
- Executive summary:
Based on experimental data on an analogue substance (reported under the endpoint records 04.21_01) the Dissociation constant for the substance defined in this dossier is estimated to be coincident to the analogue described: -1.5 ± 0.5 at 25°C for the sulfonate groups and 3.3 ± 1.4 at 25°C for the triazinyl groups.
Reference
Description of key information
Based on experimental data on an analogue substance, the dissociation constant for the substance P-1057 is estimated to be coincident to the analogue described: -1.5 ± 0.5 at 25°C for the sulfonate groups and 3.3 ± 1.4 at 25°C for the triazinyl groups.
Key value for chemical safety assessment
Additional information
Based on experimental data on an analogue substance, the dissociation constant for the substance P-1057 is estimated to be coincident to the analogue described: -1.5 ± 0.5 at 25°C for the sulfonate groups and 3.3 ± 1.4 at 25°C for the triazinyl groups.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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