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EC number: 229-942-2 | CAS number: 6850-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. details on test substance or pH value of tested solution).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-dimethylcyclohexylamine
- EC Number:
- 229-942-2
- EC Name:
- 2,6-dimethylcyclohexylamine
- Cas Number:
- 6850-63-1
- Molecular formula:
- C8H17N
- IUPAC Name:
- 2,6-dimethylcyclohexan-1-amine
- Details on test material:
- stable for 2 years; no further details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: Dr. Thomae, Biberach, Germany
Acclimatisation period:1 week
Age: 12 weeks; weight: +-20% of average weight
5 rats per cage
certified food and tap water ad libitum
food withheld 16 h prior to gavage
relative air humidity 30-70%, temperature 20-24°C, dark-light-cycle: 12h/12h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other:
- Details on oral exposure:
- The test substance was solved in aqeous solution of 0.5% carboxymethyl-cellulose (emulsion)
- Doses:
- 121, 178, 215, 261 mg/kg bw; concentrations: 1.21, 1.78, 2.15, 2.61% (w/v).
Treatment of 5 males and 5 females with a dose of 215 mg/kg bw was performed 3 months later. - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Application volume: 10 ml/kg bw
- Duration of observation period following administration: 14 days
- Frequency of observations: serveral times on the day of application, at least once daily thereafter
- Weighing: day 0, 2, 3, 7, 13
- Necropsy of survivors and rats found dead performed: yes
- Other examinations performed: clinical signs - Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 215 - < 261 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 226 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 215 - < 261 mg/kg bw
- Mortality:
- Males: all animals in the high dose group died within 24 h, all other rats survived.
Females: 1/5 rats died at 215 mg/kg bw and all rats at the high dose level. Rats died within the 1st 24 h. - Clinical signs:
- other: First symptoms occurred 30 minutes after gavage of 261 and 215 mg/kg bw; in survivors the syptoms lasted 4 h; authors described dyspnoea, apathy, staggered gait, atony, side position, twitching and poor general condition. In female rats symptoms (dyspnoea
- Gross pathology:
- No treatment related effects were detected in survivors and general congestive hyperemia in rats found dead.
- Other findings:
- no
Any other information on results incl. tables
Comment: alkalinity of test solution not measured; systemic effects not excluded.
Applicant's summary and conclusion
- Conclusions:
- In male and female rats combined the LD50 after gavage was >215 and < 261 mg/kg bw
- Executive summary:
The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. details on test substance or pH value of tested solution).
Male and female rats received via gavage the test substance at 4 dose levels (n=5 per dose per sex); the post exposure observation period was 14 days. The test substance resulted in the following clinical signs: dyspnoea, apathy, staggered gait, atony, side position, twitching and poor general condition; survivors appeared normal 4 h after gavage. The LD50 was > 215 and <261 mg/kg bw for both sexes combined.
Conclusion: In male and female rats the oral LD50 was >215 and < 261 mg/kg bw.
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