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EC number: 275-073-7 | CAS number: 70969-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline test wihout GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl 3,5,5-trimethylhexanoate
- EC Number:
- 275-073-7
- EC Name:
- 2-ethylhexyl 3,5,5-trimethylhexanoate
- Cas Number:
- 70969-70-9
- Molecular formula:
- C17H34O2
- IUPAC Name:
- 2-ethylhexyl 3,5,5-trimethylhexanoate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Sgarlat's Rabbitry, Harveys Lake, Pemnsylvania.
- Housing: Individually housed in stainless steel wire bottomed cages in an environmentally controlled room
- Diet (e.g. ad libitum): Purina rabbit pellets ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 hours light/dark cycle.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml of test material
- Duration of treatment / exposure:
- The upper and lower lids of one eye were gently held together for one second, before releasing; the eyes were not rinsed/washed afterwards.
- Number of animals or in vitro replicates:
- six healthy young, adult rabbits
- Details on study design:
- Six healthy young adult albino rabbits exhibiting no ocular defects or corneal defects were selected for testing. The test animals were each uniquely identified. One-tenth of a milliliter of the test material was placed on the everted lower lid of one eye of each rabbit. The upper and lower lids were gently held together for one second before releasing, to prevent loss of the test material. The contra lateral eye of each rabbit remained untreated and served as a control. Ocular lesions were evaluated by the method of Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: Individual scores not available from report
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- from all animals
- Time point:
- other: 24-72 hours
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: Individual scores not available from report
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the test material is considered to be non-irritating to the eyes of rabbits.
- Executive summary:
Primary eye irritation was performed to assess the irritating potential of test substance 2-ethylhexyl 3,5,5-trimethylhexanoate. Six healthy young adult albino rabbits exhibiting no ocular defects or corneal defects were selected for testing. One-tenth of a milliliter of the test material was placed on the everted lower lid of one eye of each rabbit. The upper and lower lids were gently held together for one second before releasing, to prevent loss of the test material. 2-ethylhexyl 3,5,5-trimethylhexanoate was found to cause a Maximum Mean Total Score of 0.0. at 24, 48 and 72 hours after application, and thus is considered non-irritant to eyes.
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