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Diss Factsheets
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EC number: 257-399-1 | CAS number: 51765-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from OECD SIDS report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Dossier_2996921
- Author:
- OECD HPV Chemicals Programme, SIDS Dossier, approved at SIAM 30 (20-22 April 2010)
- Year:
- 2 010
- Bibliographic source:
- SIDS Dossier_2996921; OECD HPV Chemicals Programme, SIDS Dossier, approved at SIAM 30 (20-22 April 2010)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the ocular irritation potential of trimethoxyphenyl silane
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trimethoxyphenylsilane
- EC Number:
- 221-066-9
- EC Name:
- Trimethoxyphenylsilane
- Cas Number:
- 2996-92-1
- Molecular formula:
- C9H14O3Si
- IUPAC Name:
- Trimethoxyphenylsilane
- Test material form:
- liquid: viscous
- Details on test material:
- Name of the test chemical:Trimethoxyphenylsilane
Molecular Formula:C9H14O3Si
Molecular Weigth:198.30 g/mol
InChI: 1S/C9H14O3Si/c1-10-13(11-2,12-3)9-7-5-4-6-8-9/h4-8H,1-3H3
Substance Type: Organic
Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:Trimethoxyphenylsilane
Molecular Formula:C9H14O3Si
Molecular Weigth:198.30 g/mol
InChI: 1S/C9H14O3Si/c1-10-13(11-2,12-3)9-7-5-4-6-8-9/h4-8H,1-3H3
Substance Type: Organic
Physical State: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- sex: female
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 2 drops of undiluted test chemical
- Duration of treatment / exposure:
- 0.5 minutes
- Observation period (in vivo):
- 1 hours
- Duration of post- treatment incubation (in vitro):
- no data
- Number of animals or in vitro replicates:
- 1 female rabbit
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: The left eye was washed with tepid water within 30 seconds following instillation.
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 hour
- Reversibility:
- fully reversible within: 1 hour
- Remarks on result:
- probability of weak irritation
- Irritant / corrosive response data:
- Instillation of undiluted material into the eye of a rabbit produced pain response and very slight irritation. Direct contact with the test material resulted moderate pain and conjunctival response. This effect was transient in nature and subsided in an hour..
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Instillation of undiluted material into the eye of a rabbit produced pain response and very slight irritation. Direct contact with the test material resulted moderate pain and conjunctival response. This effect was transient in nature and subsided in an hour..
Since the effects were reversible after 1 hour, trimethoxyphenyl silane can be considered not irritating to rabbit eyes.
- Executive summary:
The ocular irritation potential of Trimethoxyphenyl silane was assessed in rabbits.
2 drops of undiluted trimethoxyphenyl silane was instilled into the eyes of one female rabbit. The left eye was washed with tepid water within 30 seconds following instillation.
Instillation of undiluted material into the eye of a rabbit produced pain response and very slight irritation. Direct contact with the test material resulted moderate pain and conjunctival response. This effect was transient in nature and subsided in an hour.
Since the effects were reversible after 1 hour, trimethoxyphenyl silane can be considered not irritating to rabbit eyes.
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