Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 807-015-9 | CAS number: 126437-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Study period:
- 2004-02-17 to 2004-04-27
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Well documented guideline conform, scientific GLP report. No toxicity data are available for 1-Tetradecanaminium, N,N,N-trimethyl-, methyl carbonate (CAS No. 126437-91-0, target substance) which is used as precursor for the N,N,N-trimethyltetradecan-1-aminium oxalate (CAS No. 154858-16-9, source substance). As the chemical structure of both chemicals is almost similar with the exception of the methyl carbonate anion for the target substance instead of the oxalate, read across is made to the source substance. The available studies from the source substance are sufficient to provide toxicological information of the target substance (refer to IUCLID point 13, Assessment reports.001- Read across justification).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetradecyltrimethylammonium oxalate
- IUPAC Name:
- Tetradecyltrimethylammonium oxalate
- Reference substance name:
- -
- EC Number:
- 453-080-8
- EC Name:
- -
- IUPAC Name:
- 453-080-8
- Reference substance name:
- 154858-16-9
- Cas Number:
- 154858-16-9
- IUPAC Name:
- 154858-16-9
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g test item pasted with 0.4 mL deionized water
- Duration of treatment / exposure:
- 3 minutes (left front flank)
1 hour (left hind flank) - Observation period:
- 30 -60 minutes, 24, 48, 72 hours and 7, 14, and 21 days after patch removal
- Number of animals:
- one
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: 2.5 x 2.5 cm cellulose patch on a piece of surgical plaster (specially produced by Beiersdorf Aktiengesellschaft), covered with semi-occlusive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After the exposure period all remnants of the test substance were carefully removed from the skin with warm tap water
- Time after start of exposure: 3 minutes and 1 hour
SCORING SYSTEM: DRAIZE
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: 3 minute exposure
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- other: 72 hours
- Score:
- 2.17
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: 1 hour exposure
Any other information on results incl. tables
Table: Summary Skin irritation results:
Duration Treatment: 3 minutes (left front flank) |
|||
Female #281 |
Time after Treatment |
Erythema |
Edema |
|
30-60 min |
0 |
0 |
|
24 hrs |
0 |
0 |
|
48 hrs |
0 |
0 |
|
72 hrs |
0 |
0 |
Duration Treatment: 1 hour (left hind flank) |
|||
Female #281 |
Time after Treatment |
Erythema |
Edema |
|
30-60 min |
1 |
0 |
|
24 hrs |
2 |
2 |
|
48 hrs |
2 |
2 |
|
72 hrs |
3 |
2 |
|
7 days |
3 |
2 |
|
14 days |
2 |
0 |
|
21 day |
2 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this OECD 404 study the test substance is corrosive to skin (causes burns).
- Executive summary:
In order to test the skin irritation/corrosive properties of the test item, an OECD 404 test was performed with New Zealand White rabbits. 24 hours prior to treatment the hair of the dorsal region of the body of one rabbit was removed with an electric clipper over an area of about 25 cm2. One animal was treated sequentially with each 0.5 g of the test substance pasted with 0.4 mL deionized water for exposure periods of 3 minutes (left front flank) and 1 hour (left hind flank). The substance was administered over the whole surface of a 2.5 x 2.5 cm cellulose patch on a piece of surgical plaster. The plaster was fixed to the prepared skin area, and for the 1 hour exposure, covered with a semiocclusive bandage. After the exposure period all remnants of the test substance were carefully removed from the skin with warm tap water. Examinations of the skin areas took place after 30 - 60 minutes as well as 24, 48 and 72 hours after removal of the patches. Because of persistent irritations 72 hours after removal of the patch, additional readings were performed after 7, 14 and 21 days. Because of corrosion after treatment for 1 hour no further animals were used.
The results were evaluated numerical according to the score of DRAIZE. After the 3 minutes exposure period, no signs of irritations were observed during the study. After the 1 hour exposure period the following observations were described: 30 - 60 minutes up to 21 days after removal of the patches the treated skin of the animal showed very slight up to moderate or severe erythema and slight edema. Additionally, encrusted skin, coarse scales, as well as dry, rough and parchment-like skin surface were observed. 21 days after removal of the patch, the irritations had not disappeared and scar formation was noted in the skin indicating irreversible skin damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.