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EC number: 265-334-3 | CAS number: 65059-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Guideline followed
- GLP compliance:
- yes
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples were taken from the bath at the beginning and at the end of the experiment.
- Vehicle:
- not specified
- Details on test solutions:
- The test substance was disolved in 200 ml water, which was slowly added to the fish bath
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: west Aquarium, Bad Lauterberg, BRD
- Age at study initiation (mean and range, SD):109 days
- Length at study initiation (length definition, mean, range and SD): 30.2 mm
- Weight at study initiation (mean and range, SD): 0.28 g
ACCLIMATION
- Acclimation period: 26 days in dechlorinated tap water - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- None
- Hardness:
- 249 mg/l CaCO3
- Test temperature:
- 21.8- 24.3 °C
- pH:
- at start and each day
- Dissolved oxygen:
- at start and each day
- Salinity:
- No data
- Nominal and measured concentrations:
- The test concentrations were chosen as: 562 and 1000 ppm.
A control was carried out with the reconstituted water. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 5 liter glass aquaria; 2.9 litre
(3.0 litre minus 2x 0.05 litre for analytical control)
- Aeration:slowly aerated - Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 1 000 other: ppm
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 other: ppm
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 1 000 other: ppm
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No abnormal responses of the fish were observed.
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 after 96 h was >1000 ppm.
- Executive summary:
The acute fish toxicity of FAT 36152/D was evaluated in accordance with the EEC Directive, Annex V, Part. C.1. corresponding to the OECD-Test guidelines No.203, (1984). In the pretest the LC50 was determinated to be >1000 ppm. The test concentrations were chosen as: 562 and 1000 ppm. A control was carried out with the reconstituted water. 10 fishes per concentration and water control were used in this static system. No abnormal responses of the fish were observed. Hence, based on the findings of the study, the LC50 after 96 h was found to be >1000 ppm.
Reference
Description of key information
The 96h LC50 of the target chemical was considered to be >1000 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
The potential of test substance to cause short term toxicity to fish was investigated in three different studies. The acute fish toxicity of FAT 36152/D was evaluated in accordance with the EEC Directive, Annex V, Part. C.1. corresponding to the OECD-Test guidelines No.203, (1984). In the pretest the LC5o was determinated to be >1000 ppm. The test concentrations were chosen as: 562 and 1000 ppm. A control was carried out with the reconstituted water. 10 fishes per concentration and water control were used in this static system. No abnormal responses of the fish were observed. Hence, based on the findings of the study, the LC 50 after 96 h was found to be >1000 ppm. This study was most recently conducted and considered as a key study. Short term toxicity of FAT 36152/B to Zebra fish was investigated in a study using the methodology equivalent to OECD Guideline 203. Groups each containing 10 zebra fishes were exposed for 96 h to the test substance at 100, 300 and 1000 mg/L. No mortality was observed with any of the test concentrations. Hence, the 96 h LC0, LC50 and LC100 to zebra fish (Danio rerio) were found to be greater than 1000 mg/L (1986).
Short term toxicity of FAT 36152/A to fish was determined in a study conducted according to the methodology equivalent to OECD Guideline 203. Two groups of zebra fish, each containing 10 fishes, were exposed to test concentrations of 300 and 1000 mg/L for 96 hours. No mortality was observed with both concentrations. Hence, the 96 h LC0, LC50 and LC100 of zebra fish (Danio rerio) was considered to be greater than 1000 mg/L (1984).
No mortality or adverse effects were reported in the above discussed studies, hence the target chemical was considered to have low toxicity to fish with LC50 >1000 mg/L.
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