Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-406-3 | CAS number: 140-26-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- To assess the skin sensitizing potential of phenethyl isovalerate by Kligman human maximization assay
- GLP compliance:
- not specified
- Type of study:
- other: Maximization test
Test material
- Reference substance name:
- Phenethyl isovalerate
- EC Number:
- 205-406-3
- EC Name:
- Phenethyl isovalerate
- Cas Number:
- 140-26-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-phenylethyl 3-methylbutanoate
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report):Phenethyl isovalerate- Molecular formula (if other than submission substance):C13H1802- Molecular weight (if other than submission substance): 206.28 g/mol- Substance type:Organic- Physical state:Liquid- Analytical purity: No data available.
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- petrolatum
- Concentration / amount:
- 2%
Challenge
- Concentration / amount:
- 2%
- No. of animals per dose:
- 26 human volunteers
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: not specified
- Dose level:
- 2% in petrolatum
- No. with + reactions:
- 0
- Total no. in group:
- 26
- Clinical observations:
- No positive reaction observed
- Remarks on result:
- other: Reading: other: not specified. Dose level: 2% in petrolatum. No with. + reactions: 0.0. Total no. in groups: 26.0. Clinical observations: No positive reaction observed.
Any other information on results incl. tables
not specified
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- A maximization test was carried out on 26 volunteers. The test chemical was tested at a concentration of 2% in petrolatum and produced no sensitization reactions.
- Executive summary:
In skin sensitization study , maximization test was carried out on 26 volunteers. The test chemical was tested at a concentration of 2% in petrolatum and produced no sensitization reactions. Based on the above value ,the test material does not classify as an skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
