Registration Dossier
Registration Dossier
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EC number: 203-564-8 | CAS number: 108-24-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles (study performed in 1951)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding Toxicity Data: List IV.
- Author:
- Smyth HF et al.
- Year:
- 1 951
- Bibliographic source:
- Ind Hyg Occup Med 4: 119-122
- Reference Type:
- publication
- Title:
- Acetic acid and its derivatives: key properties and hazards.
- Author:
- Lodal PN
- Year:
- 1 992
- Bibliographic source:
- cited in: Eastman Chemical Company, Kingsport, Tennessee.
Materials and methods
- Principles of method if other than guideline:
- According to Smyth HF and Carpenter CP (1944). J indus Hyg Tox 26(8): 269-273.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Acetic anhydride
- EC Number:
- 203-564-8
- EC Name:
- Acetic anhydride
- Cas Number:
- 108-24-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- acetyl acetate
- Details on test material:
- - Name of test material (as cited in study report): acetic anhydride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other:
- Duration of exposure:
- 4 h
- Concentrations:
- 1000 and 2000 ppm (equivalent to 4.2 and 8.5 mg/L)
- No. of animals per sex per dose:
- 6
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 4.2 - 8.5 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- 4 h inhalative exposure to the test substance lead to deaths in 0/6 animals in case of the 1000 ppm dose group and in 6/6 animals in case of the 2000 ppm dose group.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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