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EC number: 225-897-8 | CAS number: 5137-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 15 May 1997 and 27 May 1997.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline Study and according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Octylphosphonic acid
- EC Number:
- 225-218-5
- EC Name:
- Octylphosphonic acid
- Cas Number:
- 4724-48-5
- Molecular formula:
- C8H19O3P
- IUPAC Name:
- octylphosphonic acid
- Test material form:
- other: White solid
- Details on test material:
- - Name in study report: Octylphosphonic acid
- Storage condition of test material: ambient temperature (<25°C), stored under artificial light over silica gel.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - Source: David Percival Ltd., Moston, Sandbach, Cheshire, UK
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.85-2.91 kg
- Fasting period before study: none
- Housing: individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-20
- Humidity (%): 52-66
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12:12
IN-LIFE DATES: from 15 May 1997 to 27 May 1997
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): no data - Duration of treatment / exposure:
- 3 minutes (3 rabbits), 1 hour and 2 hours (1 rabbit)
- Observation period:
- 12 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE (3 different sites used)
- Area of exposure: 6.25 cm2
- % coverage: no data
- Type of wrap if used: elasticated corset (TUBIGRIP)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): residual test material was removed at the end of each exposure period by gentle swabbing with cotton wool soaked in distilled water
- Time after start of exposure: 3 minutes, 1 hour and 2 hours after application.
SCORING SYSTEM:
Dermal reactions were scored according to the scale of Draize (1977).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 12 days
- Remarks on result:
- other: following 2 hour exposure period
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 12 days
- Remarks on result:
- other: following 1 hour exposure period
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 12 days
- Remarks on result:
- other: following 2 hour exposure period
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 12 days
- Remarks on result:
- other: following 1 hour exposure period
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: following 3 minute exposure period
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: following 3 minute exposure period
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: following 3 minute exposure period
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: following 3 minute exposure period
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: following 3 minute exposure period
- Irritant / corrosive response data:
- Semi-occluded applications of the test material to the intact skin of one rabbit for exposure periods of 1 hour and 2 hours produced reactions indicative of dermal corrosion. The reactions included green-coloured dermal necrosis, hardened dark brown/black-coloured scab and scar tissue. A single 3-minute semi-occluded application of the test material to the intact skin of 3 rabbits produced no corrosive effects.
- Other effects:
- None
Any other information on results incl. tables
No other information
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions of this study, OPA is classified as Skin corrosion/irritation Cat 1B: H314 (Causes severe skin burns and eye damage) according to the criteria of EC Regulation 1272/2008.
- Executive summary:
A study was performed to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit according to OECD 404 and in compliance with GLP.
Semi-occluded applications of the test material to the intact skin of one rabbit for exposure periods of 1 hour and 2 hours produced reactions indicative of dermal corrosion. The reactions included green-coloured dermal necrosis, hardened dark brown/black-coloured scab and scar tissue.
A single 3-minute semi-occluded application of the test material to the intact skin of 3 rabbits produced no corrosive effects. The mean individual scores calculated within 3 scoring times (24, 48 and 72 hours) were 0.0, 0.0, 0.0 and 1, 0.3, 0 for edema and erythema respectively after a 3 minute exposure period.
In conclusion, under the test conditions, the test item is classified as skin corrosion/irritation Cat 1B: H314 (Causes severe skin burns and eye damage) when applied topically to rabbits according to the criteria of the Regulation (EC) 1272/2008 and as skin corrosive (C-R34) according to the criteria of the Annex VI of the Directive 67/548/EEC.
This study is considered as acceptable and satisfies the requirement for skin irritation endpoint.
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