2-propylvaleronitrile

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

2017

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-propylvaleronitrile

EC Number:

236-338-2

EC Name:

2-propylvaleronitrile

Cas Number:

13310-75-3

Molecular formula:

C8H15N

IUPAC Name:

2-propylpentanenitrile

Test animals

Species:

rat

Strain:

other: Crl:WI(Han)

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

300 and 2000 mg/kg

No. of animals per sex per dose:

3 females/dose

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

>= 300 - <= 2 000 mg/kg bw

Based on:

test mat.

Mortality:

There were no deaths at a dose level of 300 mg/kg. Two animals dosed at 2000 mg/kg were found dead two days after dosing on Day 3. One other animal was humanely killed due to the severity of the clinical signs at this time point.

Clinical signs:

No clinical signs were seen at a dose level of 300 mg/kg.
Piloerection and ataxia or decreased activity were noted in all animals treated at 2000 mg/kg one day after dosing. Piloerection, ataxia, decreased activity and hunched posture were noted in these animals on Day 3. One animal treated at 2000 mg/kg was prone and gasping on Day 3 and was humanely killed. All surviving animals appeared normal from Day 4.

Body weight:

All surviving rats achieved body weight gains during the first and second weeks of the study except for one animal treated at 2000 mg/kg which showed a slight loss in body weight during the first week.

Gross pathology:

No abnormalities were noted at necropsy.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The acute median lethal oral dose level of the test article, 2-propylvaleronitrile (CAS 13310-75-3), was found to be between 300 and 2000 mg/kg.
The test material was classified as Category 4 in respect of its acute oral toxicity according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).