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EC number: 700-421-6 | CAS number: 1215122-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 08/02/1988-07/04/1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP - Guideline study, tested with the source substance. In accordance to the ECHA guidance document "Practical guide 6: How to report read-across and categories (March 2010)", the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance. It is hypothesized that the toxicity of the target chemical can be derived from the respective toxicity data of DMAs with comparable length of alkyl chain (source substances). The underlying scientific rationale is based on the physico-chemical property of the target chemical and “chain length category”.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dodecyldimethylamine
- EC Number:
- 203-943-8
- EC Name:
- Dodecyldimethylamine
- Cas Number:
- 112-18-5
- IUPAC Name:
- N,N-dimethyldodecan-1-amine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3-5 months
- Weight at study initiation: 2.5-3.4 kg
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITONS
- Temperature (°C): 20 +/- 3ºC
- Humidity (%): 50 +/- 20%
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours or 3 minutes
- Observation period:
- 30-60 minutes, 24, 48 and 72 hours after end of exposure, and after 7 and 14 days
- Number of animals:
- four
- Details on study design:
- TEST SITE
- Area of exposure: 2,5 x 2,5 cm
- % coverage: 100%
- Type of wrap if used: semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm tap water
- Time after start of exposure: 3 min or 4 h
SCORING SYSTEM:
Erythema and eschar formation
No erythema: 0
Very slight erythem: 1
Well-defined erythema:2
Moderate to severe erythema: 3
Severe erythema to slight eschar formation: 4
Oedema formation
No oedema:0
Very slight oedema: 1
Slight oedema:2
Moderate oedema:3
Severe oedema:4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- (4 h exposure)
- Basis:
- animal #1
- Time point:
- other: 30-60'
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: At the end of observation scar and eschar formation was visible
- Irritation parameter:
- edema score
- Remarks:
- (4 h exposure)
- Basis:
- animal #1
- Time point:
- other: 30-60'
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- (4 h exposure)
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- (4 h exposure)
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- (3 min exposure)
- Basis:
- animal: #2, #3, #4
- Time point:
- other: 30-60'
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: At the end of observation scar and schar fomation wee vivible
- Irritation parameter:
- edema score
- Remarks:
- (3 min exposure)
- Basis:
- animal: #2, #3, #4
- Time point:
- other: 30-60'
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: At the end of observation scar and eschar formation was visible
- Irritation parameter:
- erythema score
- Remarks:
- (3 min exposure)
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: At the end of observation eschar formation were visible
- Irritation parameter:
- erythema score
- Remarks:
- (3 min exposure)
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: At the end of observation eschar formation were visible
- Irritation parameter:
- erythema score
- Remarks:
- (3 min exposure)
- Basis:
- animal #4
- Time point:
- other: 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: At the end of observation flaked skin was visible, as well as scar and eschar formation
- Irritation parameter:
- edema score
- Remarks:
- ( 3 min exposure)
- Basis:
- animal: #2, #3
- Time point:
- other: 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- (3 min exposure)
- Basis:
- animal #4
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- 4 h exposure: 1-72 h after the end of exposure the application site was swollen, surrounded by a well-definded moderate erythema
After 7 days the edema was not evaluable due to hardening, surrounded by a severe erythema. 24 h post exposure the treated area revealed a brownish discolouration, was arched upwards, encrusted and scabbed.
3 min exposure: 24 to 72 h post exposure the animals revealed hardly perceptible to moderate erythema, 2 of 3 animals with slight edema. From 7 to 14 days the skin of 2 animals showed hardening, surrounded by hardly perceptible to moderate erythema and slight to severe edema. This was accompanied by yellowish or light brown discolouration dryness and eschar formation. The skin was scabby, arched upwards, parchmenty, fissured and crusty. One animal recovered completely, another animal had a definite scar.
Any other information on results incl. tables
4 hours | |||||
time | 30-60 ' | 24h | 48h | 72h | 7 d |
animal number | 1 | 1 | 1 | 1 | |
Erythema | 2 | 3* | 3* | 2* | 4* |
Oedema | 4 | 4 | 4 | 4 | + |
3 minutes | ||||||||||||||||||
time | 30-60 ' | 24h | 48h | 72h | 7 d | 14 d | ||||||||||||
animal number | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
Erythema | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 3* | 2* | 1 | 3* | 2* | 0 |
Oedema | 0 | 0 | 0 | 2 | 2 | 0 | 2 | 2 | 0 | 2 | 2 | 0 | 2* | 2* | 0 | 4* | 3* | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The skin irritation/corrosion of the target substance was assessed based on the analogue approach using N,N-dimethyldodecan-1-amine as read-across supporting substance. According to the current investigations, the substance N,N-dimethyldodecan-1-amine is corrosive to the skin of rabbits.
- Executive summary:
The skin irritation/corrosion of the target substance was assessed based on the analogue approach using N,N-dimethyldodecan-1-amine as read-across supporting substance.
New Zealand rabbits were treated with the test substance in an dermal irritation/corrosion study according to guidelines OECD 404 and EU B.4. 3 min of exposure produced erythema and edema scores of 1, 1.33 and 2 (erythema) and 2, 2 and 0 (edema) respectively.
This was accompanied by yellowish or light brown discolouration dryness and eschar and scar formation. The skin was scabby, arched upwards, parchmenty, fissured and crusty. One animal recovered completely, another animal had a definite scar.
After 4 hours the skin of this animal was also destructed and scar was formed. After 3 minutes in 1 animal scars were formed. The test substance is corrosive to rabbit skin.
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