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EC number: 500-086-4 | CAS number: 35238-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in a manner similar to current testing guidelines withadequate docummentation. However, the GLP regulations were not inforce during the time of study conduct.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- The study was conducted in 1977 before the existence of the GLPs.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4,4'-isopropylidenediphenol
- EC Number:
- 201-245-8
- EC Name:
- 4,4'-isopropylidenediphenol
- Cas Number:
- 80-05-7
- Molecular formula:
- C15H16O2
- IUPAC Name:
- 2,2-bis(4-hydroxyphenyl)propane
- Reference substance name:
- 4,4’-isopropylidenediphenol
- IUPAC Name:
- 4,4’-isopropylidenediphenol
- Reference substance name:
- : Phenol, 4,4’-(1-methylethylidene)bis-
- IUPAC Name:
- : Phenol, 4,4’-(1-methylethylidene)bis-
- Reference substance name:
- Bisphenol A
- IUPAC Name:
- Bisphenol A
- Details on test material:
- As per IUCLID5 Sections 1.1. -1.4. for Bisphenol A.
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rats of the Wistar strain that had been bred and reared in specific pathogen—free conditions in Shell Toxicology Laboratory (Tunstall) were used. They were 11 weeks old at the beginning of the study. No other details available.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- The dust atmosphere of Bisphenol A was generated by means of an Aeroset Powder Spray MK V (Aerostyle Ltd., London). The discharge nozzle of the spray was modified so that it discharged downwards along the central axis of a 0.5 m3 exposure chamber from a point 0.7 m above the chamber floor. The air flow through the chamber was 00l6 m3/ min.
- Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- Nominal only based on gravimetrically made determinations.
- Duration of exposure:
- 4 h
- Concentrations:
- 111 mg/m3
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- Four male and four female rats were exposed continuously to the Bisphenol A dust for four hours. The rats were restrained in cylindrical holders constructed from half—inch wire mesh which prevented them from grooming. After exposure each animal was washed in clean water, dried and then observed for seven days. The rats were then sacrficed and standard autopsy examinations were carried out. All lung lobes of each rat were removed and fixed in 10% neutral buffered formalin solution for subsequent histological examination.
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: Histological evidence of respiratory tract irritation.
- Effect level:
- 111 mg/m³ air (nominal)
- Based on:
- act. ingr.
- Exp. duration:
- 7 d
- Remarks on result:
- other: There were no mortalities.
- Mortality:
- None
- Clinical signs:
- other: Immediately after the exposure all of the rats exhibited alivation. Three of the females and two of the males showed fast respiration and slight to moderate body tremors.
- Body weight:
- no data
- Gross pathology:
- There were no macroscopic changes at autopsy which were considered to be related to the treatment.
- Other findings:
- Histological examination of the lungs revealed mild focal pen— bronchial lymphoid aggregates and perivascular eosinophil infiltration in all cases. Eosinophil infiltration was also occasionally observed in peribronchiolar and subpleural sites. Changes were frequently observed in the bronchiolar epithelium; in particular, hyperplasia, as shown by the presence of a multilayered epithelium without inflammatory cell infiltrate, occurred in seven animals. Occasional eosinophilic droplets were seen in the bronchiolar epithelium of six rats. A small focus of bronchiolitis was observed in one male rat.
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- The histological findings in the bronchiolar epithelium of rats exposed to air milled disodium bisphenol—A were considered to be indicative of a mild irritation. No other signs of intoxication were observed in the exposed animals. These data for the structural analog Bisphenol A, suggest that 2-Acetone polymer with phenol (BPA-Tars) may be a respiratory tract irritant
- Executive summary:
Air milled disodium bisphenol—A was assesssed for acute dust inhalation toxicity in male and female Wistar rats by four hours of whole body exposure. The histological findings in the bronchiolar epithelium of rats exposed to disodium bisphenol A were considered to be indicative of a mild irritation. No other signs of intoxication were observed in the exposed animals. These data for the structural analog Bisphenol A, suggest that 2-Acetone polymer with phenol (BPA-Tars) may be a respiratory tract irritant
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