Registration Dossier
Registration Dossier
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EC number: 204-289-6 | CAS number: 118-96-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- The study is in vivo as the study already available based on literature already published.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975-1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Due to absence of information on number of animal reliability category according to Klimisch is 3 (red score). Evaluator proposal is 2 (“reliable with restrictions”) because number of animals in compliance with method can be various.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Remarks:
- The study was conducted in 1975 whereas OECD and EU Guidelines as well as GLP Principles were implemented in 1981 and 1988
Test material
- Reference substance name:
- TNT
- IUPAC Name:
- TNT
- Reference substance name:
- 2,4,6-trinitrotoluene
- EC Number:
- 204-289-6
- EC Name:
- 2,4,6-trinitrotoluene
- Cas Number:
- 118-96-7
- Molecular formula:
- C7H5N3O6
- IUPAC Name:
- 2-methyl-1,3,5-trinitrobenzene
- Details on test material:
- TNT was purchased from K&K Laboratories (Cleveland, Ohio). Purity >99%.
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand
Test system
- Vehicle:
- other: 50% paste with peanut oil prepared just prior to application
- Controls:
- other: 67% suspension of lactose in peanut oil was used
- Amount / concentration applied:
- 50% paste with peanut oil
- Duration of treatment / exposure:
- 24 and 72h.
- Observation period (in vivo):
- 24 and 72h.
- Number of animals or in vitro replicates:
- 6 rabbits per test groups.
Results and discussion
In vivo
Results
- Remarks on result:
- no indication of irritation
- Other effects:
- Red pigment appeared around the eye after TNT was applied (red color around the eye at 24h). TNT did not produce eye irritation.
Any other information on results incl. tables
Not irritating.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- Not irritating according to Regulation (EC) no 1272/2008 (CLP).
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