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EC number: 203-294-0 | CAS number: 105-39-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 27.03.1979 to 29.05.1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No data on guidelines and no GLP, but the test method is similar to OECD 402.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- No guideline was followed but the test method is similar to OECD 402.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl chloroacetate
- EC Number:
- 203-294-0
- EC Name:
- Ethyl chloroacetate
- Cas Number:
- 105-39-5
- Molecular formula:
- C4H7ClO2
- IUPAC Name:
- ethyl 2-chloroacetate
- Details on test material:
- - Name of test material (as cited in study report): Monochloressigsäureäthylester
- Physical state: clear colorless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 182 g ± 7.93 g
- Housing: In individual cages
- Diet (e.g. ad libitum): Altromin 1324 (Altromin GmbH, Lage/Lipe); ad libitum
- Water (e.g. ad libitum): ad libitum; tap water
IN-LIFE DATES: From: 27.03.1979 To: 23.04.1979
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: about 30 cm2
- Type of wrap if used: the treatment area was covered with aluminum foil (6 x 8 cm) and again by a wide elastic plaster bandage (Elastoplast, fixed 8 cm) around the body of the animal.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The treated area was washed with warm water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Concentration (if solution): Undiluted
- Constant volume or concentration used: no - Duration of exposure:
- 24 hours
- Doses:
- 63, 100, 125, 160 and 250 mg/kg bw
- No. of animals per sex per dose:
- 6 females per dose, except in the highest dose, with 12 females.
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: After dermal application, symptoms of poisoning, mortality rate and timing of deaths were recorded. For 14 days, the animals were weighed weekly.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Fatally intoxicated animals were dissected and macroscopically examined at autopsy. The surviving animals were euthanized with CO2 gas, dissected and also macroscopically examined. - Statistics:
- The LD 50 was calculated using Probit (method according to Linder and Weber). The confidence limits were calculated according to Cavalli-Sforza (Department of Applied Mathematics of Hoechst).
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 161.2 mg/kg bw
- 95% CL:
- 129.2 - 201.1
- Mortality:
- In the dose groups of 63 and 100 mg/kg no mortalities were observed. In the dose group of 125 mg/kg there were 2 (of 6) deaths. In the group of 160 mg/kg, 5 (of 6) animals died, and in the highest dose group 9 (of 12). All animals died between 147 minutes and 9 days post exposure.
- Clinical signs:
- other: Animals that died during the study had the following clinical symptoms: restlessness, abdominal position, passivity, stupor, rufflef fur, narrowed eye lids and increased lacrimation. The surviving animals recovered from the symptoms within 24-48 hours af
- Gross pathology:
- The autopsy of the animals that were fatally poisoned showed: lungs brownish red and blotchy, liver intense and dark blood color. In some animals, bladder and rectum were filled with a dark brown-black liquid with signs of autolyse.
In animals sacrificed at the end of the study, macroscopic studies were normal, without any visible alterations.
Any other information on results incl. tables
Table 07.02.03_01. Mortality
Dose (mg/kg bw) | Concentration | Mortality rate (death animals/ treated animals) |
63 | Undiluted | 0/6 |
100 | Undiluted | 0/6 |
125 | Undiluted | 2/6 |
160 | Undiluted | 5/6 |
250 | Undiluted | 9/12 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD 50 was 161.2 (129.2 - 201.1) mg/kg body weight.
- Executive summary:
A study of the acute dermal toxicity was performed on female Wistar rats. At the end of an observation period of 14 days, a LD 50 of 161.2 (129.2 - 201.1) mg/kg body weight was determined by Probit.
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