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EC number: 205-769-8 | CAS number: 150-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 23 sept 2008 to 19 dec 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, carried out without any deviations to the guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD No 423 Acute Oral Toxicity – Acute Toxic Class Method
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Mequinol
- EC Number:
- 205-769-8
- EC Name:
- Mequinol
- Cas Number:
- 150-76-5
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 4-methoxyphenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories Ltd
- Age at study initiation: 9 weeks for males and 11 weeks for females
- Weight at study initiation: 187.3 g - 263.0 g
- Fasting period before study: no fasting period
- Housing: individually in Makrolon type-3 cages with standard softwood bedding
- Diet (e.g. ad libitum): pelleted standard Provimi Kliba 3433 rat/mouse maintenance diet
- Water (e.g. ad libitum): community tap water from Füllinsdorf
- Acclimation period: 7/8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C
- Humidity (%): 30 - 70%
- Air changes (per hr): air-conditioned with 10-15 airs changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours light and 12 hours dark
IN-LIFE DATES: From: 01 oct 2008 To: 15 oct 2008
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: purified water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back of animals, skin area of 12 cm2 and 9 cm2 in the males and females
- % coverage: approximately 10% of the total body surface
- Type of wrap if used: a surgical gauze patch
TEST MATERIAL
- Concentration: 2000 mg/kg bw
- Concentration used: yes
- For solids, paste formed: yes
VEHICLE
- Amount(s) applied: 0.1 mL - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations: during the first 30 minutes, at approximately 1, 2, 3 and 5 hours after administration on test day 1 and twice daily for viability / Mortality and once daily for clinical signs during days 2-15
- Weighing : on test days 1 (prior to administration), 8 and 15
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight, macroscopic examination - Statistics:
- no statistical analysis was used
Results and discussion
- Preliminary study:
- A single animal of each sex was treated first. Since no death as well as no severe local effects or severe systemic symptoms were observed after the 24-hour exposure, the test was completed using the four remaining male and female animals for an exposure period of 24-hours.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no deaths occured during the study
- Clinical signs:
- other: No clinical signs were observed in all 5 males and 5 females within the first 30 minutes following the treatment. No severe clinical signs were observed in all animals. Only slight signs were observed such as: - ruffled fur: in 4 males and 1 female at the
- Gross pathology:
- No macroscopic findings were recorded at necropsy.
- Other findings:
- Local dermal signs
Delayed local dermal reactions were observed in all males and females and consisted of erythema, oedema, scaling, focal to maculated crusts. The skin was affected from test day 3 to 5 (in most of the animals) to test day 7, 8, 11, 12 or up to the end of the observation (test day 15).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD 50 (rat): greater than 2000 mg/kg body weight
- Executive summary:
In an acute dermal toxicity study B96175, groups of 5 Wistar male and 5 Wistar female rats were dermally exposed to Paramethoxyphenol for 24 hours to 10% of the total body surface at dose of 2000 mg/kg bw.
Animals then were observed for 15 days.
Dermal LD50 > 2000 mg/kg bw
Paramethoxyphenol is not classified based on the LD50. (PMP is also not officially classified)
Slight clinical signs (sedation and ruffled fur) and local signs (erythema and scaling crusts) were generally observed in almost all animals. There were no treatment related macroscopic examination or changes in body weight.
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