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EC number: 284-660-7 | CAS number: 84961-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb. 16, 1993-Feb. 19. 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test substance was added to demineralized water at 1g/L and stirred for 18 hrs. - Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Source (laboratory, culture collection): Aus dem Institut fur Wasser-, Boden-, und Lufthygiene - Test type:
- static
- Total exposure duration:
- 72 h
- Test temperature:
- 24 +/- 2°C
- pH:
- 7.3 to 7.7 at test initiation and from 8.9 to 9.3 at 72-hours
- Nominal and measured concentrations:
- Nominal test concentrations were 0.23, 0.39, 0.69, 1.16 and 2.08 mg/L, plus a control.
- Details on test conditions:
- TEST SYSTEM
- Material, size, headspace, fill volume: Erlenmeyer flasks
- Initial cells density: 20,000 cells/ml
- No. of vessels per concentration (replicates): 8
- No. of vessels per control (replicates): 8
GROWTH MEDIUM
- Standard medium used: yes
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Light intensity and quality: 8000 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: spectrophotometer
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 2.08 mg/L
- Nominal / measured:
- nominal
- Duration:
- 72 h
- Dose descriptor:
- other: EbC50
- Effect conc.:
- > 2.08 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- other: ErC50
- Effect conc.:
- > 2.08 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 72-hr ErC50 and EbC50 was > 2.08 mg/L test substance. This represents the solubility limit of the test substance.
- Executive summary:
This study examined the potential of the test substance to cause toxicity to aquatic algae. Algae of the species Scenedesmus subspicatus were exposed to concentrations of 0, 0.23, 0.39, 0.69, 1.16 and 2.08 mg/L of test substance. The 2.08 mg/L concentration represents the solubility limit of the test substance. Algae were exposed for 72 hrs. Observations for biomass and growth rate were made at 24, 48, and 72 hrs after start of exposure. No reduction in either of these parameters as compared to controls was seen. The 72 -hr ErC50 and EbC50 was > 2.08 mg/L of test substance. The NOEC was >= 2.08 mg/L of test substance. The 72 -hr ErC50 and EbC50 are therefore greater than the solubility limit of the test substance.
Reference
Cell Growth ( x 104cells/ml)
Concentration |
0 hrs |
24 hrs |
48 hrs |
72 hrs |
Control |
2 |
6 |
24 |
69 |
0.23 mg/l |
2 |
6 |
24 |
68 |
0.39 mg/l |
2 |
6 |
24 |
79 |
0.69 mg/l |
2 |
6 |
26 |
78 |
1.16 mg/l |
2 |
6 |
26 |
80 |
2.08 mg/l |
2 |
6 |
26 |
77 |
Description of key information
The key study examined the potential of HAB to cause toxicity to aquatic algae. Algae of the species Scenedesmus subspicatus were exposed to concentrations of 0, 0.23, 0.39, 0.69, 1.16 and 2.08 mg/L of test substance. The 2.08 mg/L concentration represents the solubility limit of the test substance. Algae were exposed for 72 hrs. Observations for biomass and growth rate were made at 24, 48, and 72 hrs after start of exposure. No reduction in either of these parameters as compared to controls was seen. The 72 -hr ErC50 and EbC50 was > 2.08 mg/L of test substance. The NOEC was >= 2.08 mg/L of test substance. The 72-hr ErC50 and EbC50 are therefore greater than the solubility limit of the test substance.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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